Meta-analysis Of The Correlation Between BV,TV,VVC And Cervical HPV Infection

Objective:The International Agency for Research on Cancer had shown that HPV infection was closely related to anal genital tract tumors.There was literature suggesting that vaginal microbiota disorders could lead to the persistence of cervical HPV infection.Bacterial vaginosis(BV),trichomonas vaginitis(TV)and vulvovaginal candidiasis(VVC)were the three most commonly seen vaginitis in gynecology.This article aimed to use the meta-analysis method to explore the correlation between these three common vaginitis and cervical HPV infection,and to provide evidence-based medical basis for preventing and eliminating of cervical HPV infection.Methods:The computer searched for CNKI,Wanfang,VIP,Pubmed,Ovid-Medline and Embase databases to collect Chinese and English literature or journals published from the earliest available data to May 1,2018.The literature was screened according to the established inclusion and exclusion criteria,the quality of the literature was evaluated,the valid data in the literature was extracted,and Meta analysis was performed using Stata 12.0 software.The literature included in this study was a two-category variable,so the odds ratio(OR)was used as the effect value of the outcome index,and the OR combined value and 95% confidence interval(95% CI)were calculated.According to the results of heterogeneity test,the appropriate effect model was selected.When the heterogeneity was high,a subgroup analysis could be performed to analyze the heterogeneity source.The publication bias was identified using a funnel plot method,Begg and Egger tests.Based on the sensitivity analysis,we can judge whether the results are reliable and stable.Results:1.According to the established inclusion and exclusion criteria,33 documents were finally included,all of which were cross-sectional studies;2.Meta-analysis of the association between BV and cervical HPV infection: 26 articles were eventually included,of which 7178 were HPV-infected patients and21,513 were in the control group.The combined OR and 95% CI were 2.63(2.04,3.37).It is suggested that BV is associated with HPV infection in the cervix.The risk of cervical HPV infection in patients with BV is about 2.63 times that of non-BV patients.The Begg and Egger test showed no publication bias,and the sensitivity analysis confirmed that the conclusion was stable and reliable.3.Meta-analysis of the correlation between TV and cervical HPV infection: 25 articles were finally included,of which 7430 were HPV-infected patients and 21103 were in the control group.The combined OR and 95% CI were 1.44(1.01,2.04).It is suggested that TV and cervical HPV infection are related.The risk of cervical HPV infection in TV patients is about 1.44 times that of non-TV patients.The Begg and Egger test showed no publication bias,and the sensitivity analysis confirmed that the conclusion was stable and reliable.4.Meta-analysis of the correlation between VVC and cervical HPV infection:28 articles were finally included,of which 6424 were HPV-infected patients and20040 were in the control group.The combined OR and 95% CI were 1.41(1.01,1.98).It is suggested that VVC is associated with cervical HPV infection.The risk of cervical HPV infection in VVC patients is about 1.41 times higher than that in non-VVC patients.The Begg and Egger test showed no publication bias,and the sensitivity analysis confirmed that the conclusion was stable and reliable.Conclusion:1.BV and cervical HPV infection are correlated,and the incidence of cervical HPV infection in BV patients increases;2.TV and cervical HPV infection are correlated,and the incidence of cervical HPV infection in TV patients increases;3.VVC and cervical HPV infection are correlated,and the incidence of cervical HPV infection in VVC patients increases;4.The change of the internal environment of the vagina is one of the reasons for cervical susceptibility to HPV.