Study On The Relationship Between Helicobacter Pylori Infection And Migraine

Purpose:To explore the correlation between Helicobacter pylori infection and migraine in order to provide new ideas for the study of the pathogenesis and clinical treatment of migraine.Methods:110 migraine patients who were tested for Helicobacter pylori in hospital from September 2017 to January 2018.Among 110 migraine patients,there are 90 patients with complete data were selected as migraine group.120 patients who were admitted to the physical examination center of our hospital at the same time were selected as the healthy control group.The HP infection rates between migraine group and healthy control group and between different subtypes of migraine were compared.According to whether they were infected with HP or not,the migraine group was divided into HP positive group and HP negative group.The clinical data such as age,sex,course of disease,family history,aura,accompanying symptoms,headache degree,headache frequency and headache duration were counted respectively.The relationship between headache characteristics and HP infection was analyzed retrospectively.SPSS21.0 statistical software was used to process the data.There was significant difference between the two groups(P < 0.05).Results:1.The infection rate of HP was 22.5% in healthy control group and53.33% in migraine group.The infection rate of HP in migraine group was significantly higher than that in healthy control group(P < 0.05).The infection rates of HP in patients with aura migraine and non-aura migraine were 59.26% and 49.21%.There was no significant difference in HP infection rate between the two groups(P > 0.05).2.Correlation between headache characteristics and HP infection in migraine patients: Compared with HP negative group,HP positive group had more severe headache,higher frequency of headache attack and higher comprehensive headache score in migraine patients.There was significant difference between the two groups(P < 0.05).3.The infection rates of HP in migraine patients with headache degree 2,4 and 6 were 38.24%(13/34),57.89%(11/19)and 64.86%(24/37).The infection rates of HP in mild headache group,moderate headache group and severe headache group were 42.11%(8 /19),46.3%(25/ 54)and 88.24%(15/17).Except for mild headache group and moderate headache group,there was significant difference between the two groups.4.Correlation between HP infection subtypes and migraine characteristics: Helicobacter pylori was divided into type ? and type ?according to the existence of two important virulence factors: vacuolar cytotoxin(vacA)and cytotoxicity-related gene A(cagA)coding protein.Migraine patients with type I HP infection had more severe headaches and higher headache comprehensive scores than migraine patients with type ?HP infection.There was significant difference between the two groups(P <0.05),but there was no significant difference in other headache characteristics(headache symptom score,headache frequency score,headache duration score)between the two groups(P > 0.05).Conclusion:1.The high prevalence of HP in migraine patients suggests that HP may be a risk factor for migraine.2.Migraine patients with HP infection have more severe headache and greater harm.3.Migraine patients with type I HP infection have more severe headache and higher headache comprehensive score than those with II HP infection migraine,suggesting that different subtypes of HP infection have different effects on migraine,and its internal mechanism is worthy of further study.