Therapeutic Effect Of Radiofrequency Ablation And Surgical Resection For Liver Cancer Metastasis Of Colorectal Cancer

Purpose:To analyze the difference of safety,efficacy and long-term efficacy between radiofrequency ablation(RFA)and surgical resection in the treatment of liver metastases from rectocellular carcinoma(CRLM),so as to provide basis for the treatment of patients with liver metastases from rectocellular carcinoma(CRLM).Methods:A retrospective analysis of 72 patients with liver metastases after radical resection of colorectal cancer from September 2009 to December2013(maximum liver metastases≤3 cm,number of metastases≤5)Follow-up observations were performed.Of these,39 patients underwent RFA(RFA treatment)and 33 underwent hepatectomy(surgical resection).The differences of operation time,intraoperative bleeding volume,total hospitalization time,total hospitalization fee,incidence of postoperative complications,overall survival rate and tumor-free survival rate between the two groups were analyzed and compared.Results:Both groups of patients achieved the effect of completely removing liver metastases and were discharged smoothly.There were no deaths within one month after surgery.The average operation time of the RFA treatment group and the surgical resection group were 53.36±9.12 min and 141.30±23.32 min,respectively.The average intraoperative blood loss in the RFA treatment group and the surgical resection group were30.26±8.58 ml and 298.48±84.30 ml,respectively;RFA treatment The average hospitalization time of the group and the surgical resection group were 4.74±1.02d and 14.09±1.81d,respectively.The average hospitalization expenses of the RFA treatment group and the surgical resection group were 1.50±0.16 million and 5.06±0.86 million,respectively.In the above two groups,the RFA treatment group was superior to the surgical resection group,and the difference was statistically significant(P<0.05).The incidence of postoperative complications in the RFA-treated group and the surgical resection group were 5.13%and 30.30%,respectively.The RFA-treated group was superior to the surgical resection group,and the difference was statistically significant(P<0.05).In terms of long-term efficacy of CRLM patients,RFA treatment group:The survival rates at 1,3,and 5 years were 94.9%,61.5%,and 41.0%,respectively;Surgical resection group:1,3,and 5 years survival rates were 97.0%,69.7%,and 42.4%,respectively.there was no significant difference between the two groups(P>0.05).There was no significant difference in overall survival between the two groups(χ~2=0.068,P=0.794>0.05).There was no significant difference in overall tumor-free survival rate between RFA treatment group and surgical resection group(χ~2=0.286,P=0.593>0.05).This shows that there is no difference in long-term efficacy between the two groups of patients.Conclusion:For patients with liver metastasis of colorectal cancer with a maximum diameter of≤3cm and a number of≤5,the treatment of RFA is less invasive,less expensive,safe and effective;Compared with surgical resection,RFA can reduce the physical and mental and economic stress of patients,and the long-term efficacy is similar;RFA can be used as an effective alternative to liver metastases in colorectal cancer.