Study On The Correlation Between Chronic Obstructive Pulmonary Disease And Stroke

Objective:Chronic obstructive pulmonary disease(COPD)is one of the diseases with the highest morbidity and mortality in the world,and mortality has increased significantly in recent years.In patients with COPD,the incidence of neurological diseases such as stroke,cerebrovascular disease and cognitive impairment is very common,especially the incidence of stroke is significantly higher than that in the general population.In recent years,many scholars have begun to study the mechanism of interaction between respiratory and nervous system diseases.More and more research results show that the scope of COPD is not limited to the lungs,but also involves the nervous system.This article compares the incidence of stroke in patients with COPD and non-COPD,explores the correlation between COPD and stroke,and further analyzes of the influence of gender,age,decline in lung function,smoking history,season,COPD duration and other factors on the two,and enhance the understanding of early prevention and treatment of COPD,in order to understand the proportion of stroke and population distribution characteristics of COPD patients,it provides a clinical basis for reducing the mortality,morbidity and incidence of concurrent stroke and other complications of COPD patients.Materials and Methods:A total of 1215 patients with COPD diagnosed in the China-Japan Union Hospital of Jilin University from January 2015 to March 2018 were enrolled.The patients were diagnosed with a detailed history of medical history and related examinations(thoracic CT,pulmonary function tests,etc.).A total of 1215 non-COPD subjects who were admitted to the physical examination center of the China-Japan Union Hospital of Jilin University at the same time were selected as the control group.All of them were from the same area,matched by age and gender,and had no history of COPD,stroke and family history.The selection of the two groups of people met the inclusion criteria and exclusion criteria.According to the age segment determined by the United Nations World Health Organization,the observation group and the control group were divided into a youth group(<45 years old),a middle-aged group(45-59 years old)and an elderly group(?60 years old);The observation group and the control group were divided into a male group and a female group.By comparing the probability of stroke events between the observation group and the control group during the follow-up period from January 2015 to March 2018,to assess the correlation between COPD and stroke,the incidence of concomitant stroke in COPD patients was different.The differences in gender,age,degree of lung function decline,smoking history,season,and duration of COPD were used to understand the proportion of patients with COPD complicated with stroke and the distribution characteristics of the population.Results:1.In the observation group,132 patients had stroke complicated,accounting for 10.86%.In the control group,13 patients had stroke,accounting for 1.07%,the difference was statistically significant(P<0.01).2.The proportion of stroke patients with COPD in different age groups(<45 years old,45-59 years old,?60 years old)in the observation group was 3.66%,6.20%,and 15.50%,respectively,and the incidence increased with age.The difference was statistically significant(P<0.01).The proportion of stroke patients in different age groups was 0.35%,1.17%,1.34%,and the incidence increased slightly with age,but the difference was not statistically significant(P>0.05);the difference in the proportion of stroke in the two groups of the same age group was statistically significant(P<0.05);3.The incidence of stroke in men in different age groups(<45 years old,45-59 years old,?60 years old)in the observation group was 4.17%,7.18%,18.97%,respectively.The incidence of stroke in female patients was 2.47%,4.40%,and 8.18%,respectively.The incidence of stroke in males was higher than that in females,and the difference was statistically significant(P<0.01).The proportion of strokes in males and females in the control group was 1.12% and 0.98%,respectively,the difference was not statistically significant(P>0.05);4.In the observation group,there were 273 patients with GOLD grade1 and 19 patients with stroke,accounting for 6.96%;584 patients with GOLD grade 2,58 patients with stroke,accounting for 9.93%;230 patients with GOLD grade 3 31 patients with concurrent stroke,accounting for13.48%;128 patients with GOLD grade 4,and 24 patients with stroke,accounting for 18.75%.The incidence of COPD complicated with stroke increased with the increase of airflow limitation,that is,the decline of lung function,and the difference was statistically significant(P<0.05);5.There were 813 smokers in the observation group,of which 109 cases were complicated by stroke,accounting for 13.41%;402 cases were without smoking history,23 cases were complicated by stroke,accounting for 5.72%,the difference was obvious statistical significance(P<0.01);6.In the observation group,there were 359 patients with a disease course greater than 10 years,71 patients with stroke,477 patients with a disease course of 5-10 years,45 patients with stroke,379 patients with a disease duration less than 5 years,and 16 patients with a stroke.The incidence of stroke in the observation group increased with the progression of COPD,and the difference was statistically significant(P<0.01).Observed combination and stroke patients during the follow-up period improved 27 cases,accounting for 20.45%,progress(disability and death)105 cases,accounting for 79.55%.In the control group,5 patients with stroke were improved during the follow-up period,accounting for38.46%,and progress(disability and death)in 8 cases,accounting for61.54%.In the observation group,132 patients with COPD complicated with stroke had 38 cases in spring,accounting for 28.78%;21 cases occurred in summer,accounting for 15.91%;26 cases occurred in autumn,accounting for 19.70%;47 cases occurred in winter,accounting for 35.61%.The incidence rate in winter and spring is significantly higher than that in summer and autumn,suggesting that COPD complicated with stroke has obvious seasonality.Conclusions:1.COPD is one of the important risk factors for the occurrence and development of stroke;2.The incidence of stroke complicated with COPD is positivelycorrelated with age,and The incidence of men in the same age group is higher than that of women;3.The incidence of stroke complicated with COPD is positively correlated with the degree of decline in lung function.The higher the incidence of stroke in patients with poor lung function,the slower progression of lung function may reduce the incidence rate of COPD complicated with stroke;4.Smoking history,season,and COPD duration may have an impact on COPD complicated with stroke.Early assessment of relevant risk factors is of great value in the prevention and prognosis of patients with COPD complicated with stroke.