Diagnostic Status And Risk Factors Investigation Of Chronic Obstructive Pulmonary Disease

Research background: Chronic obstructive pulmonary disease(COPD) is a major cause of disability and death worldwide. Its prevalence and mortality are still increasing,therefore COPD remains a relevant public health problem. COPD is projected to rank fifth in 2020 in burden of disease caused worldwide and will become the third-leading cause of death worldwide by 2020. But fewer than half are diagnosed early. Many adult cigarette smokers have airway obstruction, but this is not diagnosed by their physicians. The estimate of the prevalence of COPD in a country is low when only the respiratory symptoms are determined by a questionnaire. Objective measurement of lung function by spirometry is needed to investigate the true prevalence of COPD. COPD is a disease that the etiological factor and pathogenesis are uncertain entirely, and it is a preventable, treatable disease currently. Smoking is one of the major risk factors for the development of COPD. Genetic susceptibility, infection, occupational environment, air pollution and socio-economic status are also risk factors. However, there is no medication which can slow the progression of COPD, the only way to affect the prognosis and control the current COPD epidemic is early detection of the disease combined with effective anti-smoking counselling and smoking cessation. So studying the characteristics of COPD, early diagnosis and reasonable precautions that we urgently need to resolve.Objective:?To survey the diagnosis of chronic obstructive pulmonary disease (COPD) and relevant risk factors. To provide policy of prevention and treatment for COPD. To emphasize the need of spirometry.Methods: Between April to December 2009,we investigated 638 subject over 40 years of people who examed in the Anhui Provincial Hospital. It included respiratory Questionnaire, lung function test, serum SOD3 concentration estimation, physical examination, X-ray. Basing on the data character and study objective we adopted different statistical analysis. All data was analyzed with SPSS for Windows 17.0, a =0.05 was taken for test level.??Results:? (1).Only 32% (23 of 73 patiens) with COPD were diagnosed before this survey .(2).Each layer detection rate was compared withχ2 test,COPD detection rate increases along with age. The male detection rate is higher than female. COPD detection rate declines along with educational degree. The detection rate of having family history is higher than non's. And all the difference shows statistically significant. (3).Risk factors analysed with one-way non-conditional logistic regression are as follow: Using coal time are risk factors of COPD. Smoking, smoking index show significant association with COPD. Years old, family history, history of respiratory tract infection in childhood are risk factors of COPD. However,education degree is protective factor. Compared with non-COPD subjects,BMI was significantly lower in COPD patients.BMI decreased with the increase of the stage of COPD.The quality of survival shows that non-COPD subject is better than COPD's.There is relationship between X-ray result and lung function result using t-test andχ2 test. (4). SOD3 concentration decreased with the increase of the stage of COPD. ?Conclusions: (1).Our study suggests that routine spirometry in physical checkup,particularly in those≥40 years old ,men,long-term smokers.(2).The detection rate of COPD is different along with the difference of age,sex, educational degree and family history. (3).Using coal time,smoking, smoking index, age and family history are all risk factors of COPD. Education degree is a protective factor of COPD. (4).There is some relationship between X-ray result and lung function result. ? ?...