An Inquiry Into The Clinical Efficacy And Safety Of Miasmic Decoction In The Treatment Of Glucose Tolerance Disorder Of Spleen Deficiency With Damp-heat Syndrome

Objective: To observe the clinical effect of Pidanyin on patients with impaired glucose tolerance and explore the clinical efficacy of Pidanyin in treating impaired glucose tolerance,so as to provide new ideas and methods for clinical treatment of impaired glucose tolerance in TCM.Methods: From January 2017 to June 2018,clinical data of 60 outpatients in the Department of Endocrinology,Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine were collected.Following the principle of complete randomized control,according to inclusion criteria and exclusion criteria,60 patients who met the research criteria were randomly divided into control group and treatment group,30 cases in each group.There was no significant difference in age,sex,weight,nutritional status and onset time(P>0.05).The control group was given a controlled diet combined with appropriate exercise and other basic treatments.The changes of blood glucose,BMI,WHR,FINS,Hb A1 c and HOMA-IR were compared before and after treatment.Results: There was significant difference between FPG and 2h PG in the treatment group(P<0.05).The FPG of the control group decreased compared with that before treatment,but there was no significant difference before treatment(P>0.05).2h PG was more obvious than before treatment.Decreased,there was a significant difference compared with before treatment(P<0.05),After treatment,there were significant differences between the two groups in FPG and 2h PG(P<0.05).After treatment,FINS and insulin resistance index in the treatment group were significantly lower than those before treatment(P<0.05),while those in the control group were not significantly lower than those before treatment(P>0.05).There were significant differences in FINS and insulin resistance index between the two groups after treatment(P<0.05).There was no significant difference in Hb A1 c between the two groups after treatment(P>0.05).There was no significant difference in Hb A1 c between the two groups after treatment(P>0.05).After treatment,BMI and WHR in both groups decreased slightly,but there was no significant difference compared with before treatment(P>0.05).There was no significant difference in BMI and WHR between treatment group and control group(P>0.05).Conclusion:While the treatment group in regulating Hb A1 c and foundation treatment has no obvious differences,but in alleviating symptoms of TCM syndrome spleen deficient patients with abnormal glucose tolerance,improveing BMI and WHR score,reducing FPG,2HPG and FINS and insulin resistance index is better than that in control group,and the glucose tolerance abnormal syndrome patients to spleen deficient despair an illusion of water treatment in January above can achieve the effect that reduce weight,No obvious adverse reactions occurred during the clinical observation period,so it is worthy of further clinical application.