The Synergistic Effects Of Orthokeratology Combined With 0.01% Atropine In Slowing The Progression Of Juvenile Myopia

Objective: To investigate the synergistic effects of orthokeratology(OK)combined 0.01% atropine ophthalmic solution in slowing the progression of juvenile myopia.Method: 64 children of juvenile myopia aged 9–14 years with a spherical equivalent refractive error of-1.50 to-6.00 diopters were included.Total of participants who had been wearing the OK lenses successfully were randomly allocated into two groups to receive either the combination of OK and 0.01% atropine ophthalmic solution(combination group)or monotherapy with OK(monotherapy group).Subjects in the combination group started to use atropine 0.01% ophthalmic solution once nightly from 3 months after the start of OK.AL?UCVA?IOP and corneal endothelial cell density measured at month 3 of OK therapy was used as the baseline value in both groups,The change of them over 1 year was compared between the two groups.Results: A total of 64 consecutive subjects(31 subjects in the combination group and 33 in the monotherapy group)were followed for 1 year.The increase in axial length over 1 year was 0.12 ± 007 mm in the combination group and 0.22 ± 0.08 mm in the monotherapy group(P = 0.0356,unpaired t test).There was no statistically significant difference in UCVA between the two groups after a one-year observation period.There was no statistically significant difference in corneal endothelial cell density and IOP change between the two group.Conclusion: During the 1-year follow-up,the combination of OK and 0.01% atropine ophthalmic solution was more effective in slowing axial elongation than OK monotherapy in children with juvenile myopia.The use of 0.01% atropine in patients with OK lens will not affect the UCVA?corneal endothelial cell density and IOP,It is safe to use in the short term.