| Objective:This subject evaluates the clinical efficacy of Kangliu Sanjie Decoction combined with conventional chemotherapy in the treatment of non-Hodgkin lymphoma(phlegm-qi stagnation type)through clinical trial observation.To provide theoretical and practical references for the standardized treatment of non-Hodgkin's lymphoma with integrated traditional Chinese and western medicine.Methods : From July 2017 to July 2018,64 cases of non-Hodgkin lymphoma patients with clear western medicine pathological diagnosis and TCM diagnosis of phlegm-qi stagnation type were collected in the oncology department of Shanxi big hospital.they were randomly divided into experimental group(anti-tumor Sanjie decoction combined with CHOP chemotherapy)32 cases and control group(only conventional CHOP chemotherapy)32 cases.21 days was a treatment cycle.after 4 cycles of treatment,3 cases fell off.61 cases were actually included in the study,31 cases in the experimental group and 30 cases in the control group.After the treatment,the clinical efficacy of western medicine and traditional Chinese medicine were evaluated for the two groups of patients.The differences of TCM symptom score,KPS score,serum LDH value,toxicity index WBC,Hb,PLT and liver and kidney function before and after treatment were observed.Statistical analysis was conducted by SPSS21.0,P<0.05.Results:1.Western medicine clinical curative effect evaluation: after 4 cycles of treatment,the experimental group had 6 cases of CR(19.35%),11 cases of CRU(36.67%),10 cases of PR(32.26%),4 cases of relapse/progression(12.90%),and the overall remission rate was87.10%;In the control group,CR was 3 cases(10%),CRU was 6 cases(20%),PR was13 cases(43.34%),relapse/progression was 8 cases(26.66%),and the overall remission rate was 73.34%.After rank sum test,the result is P<0.05,the difference is statistically significant,which shows that the curative effect of the experimental group is better than that of the control group.2.Clinical efficacy of traditional Chinese medicine: the total effective rate after treatment in the experimental group was 90.32 %,while that in the control group was63.34%,with statistically significant difference between the two groups(P<0.05).As far as the improvement of single TCM symptoms is concerned,the TCM symptom scores inthe experimental group are significantly decreased,and the tested P values are all less than0.05.The difference is statistically significant,indicating that the clinical efficacy of TCM in the experimental group is better than that in the control group.3.KPS score: KPS score(85.16±9.26)in the experimental group and(79.33± 8.28)in the control group after treatment,and there is a statistical difference between the two groups(P < 0.05),which indicates that the body function state of the patients in the experimental group is better than that in the control group after treatment.4.Serum LDH: after treatment,the LDH values of the two groups of patients were compared with the LDH values before treatment,and the paired t test showed that P<0.05.the difference was statistically significant,indicating that both groups were effective.Compared with the control group,the independent sample t test showed that P<0.01,the difference was statistically significant,indicating that the experimental group was better than the control group in reducing serum LDH.5.Evaluation of toxicity and side effects: WBC,Hb,PLT in blood: WBC,PLT,Hb in control group decreased significantly after treatment compared with before treatment(P<0.05);There was no significant change in WBC and PLT values in the experimental group compared with that before treatment(P>0.05),Hb was higher than that before treatment,and the difference was statistically significant(P<0.05).The comparison between the two groups before and after treatment showed that the difference was statistically significant(P<0.05).Before and after treatment,the AST,ALT,BUN and Cr values of the patients did not change significantly(P>0.05).Conclusion:1.Anti-tumor Sanjie Decoction combined with CHOP chemotherapy can not only improve the clinical efficacy of phlegm-qi stagnation type non-Hodgkin lymphoma patients,but also has significant efficacy in improving the clinical symptoms of patients.2.Anti-tumor Sanjie Decoction can reduce the toxic and side effects of chemotherapy,improve the quality of life of patients and improve the dependency of patients,which is worthy of further promotion and application in clinical practice. |
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