Multivariate Analysis Affecting Prostate Puncture Results In The Range Of 4?20ng/ml

Objective:To evaluate the factors affecting the results of prostate biopsy in patients with PSA in the range of 4.0~20.0ng/ml.Method:Retrospective analysis from January 2014 to May 2018 in our hospital to check the PSA between 4.0ng ~ 20.0ng / ml parallel prostate biopsy patients with 242 cases.The influencing factors of prostate system puncture results under rectal ultrasound were analyzed by Student's t test,Chi-square test,binary logistic regression analysis and ROC curve.Result:The age of the patients in this study was 67.91±7.45 years,and the median age was 68 years.The age of patients with positive puncture was 69.04±7.31 years old,and the age of patients with negative puncture was 66.55±7.17 years old,comparison between groups was statistically significant(P<0.05);The TPSA of patients with positive and negative puncture results were 11.61±4.23ng/ml and 11.45±4.06ng/ml,comparison between groups was not statistically significant(p>0.05);The F/TPSA value of the positive patient with a puncture result was 0.13±0.08,and the F/TPSA value of the positive patient with a puncture result was 0.17±0.09,comparison between groups was statistically significant(P<0.05);The PSAD value of the positive patient with puncture was 0.33±0.23,and the negative result was 0.19±0.12,comparison between groups was statistically significant(P<0.05);The(F/TPSA)/PSAD values for the positive and negative patients were 0.86±1.46 and 1.32±1.39,comparison between groups was statistically significant(P<0.05).In this study,the detection rates of prostate cancer in patients ?68 years old and >68 years old were 17.19%(22/128)and 28.95%(33/114),comparison between groups was statistically significant(P<0.05);The detection rate of positive prostate cancer was 31.25%(10/32),and the detection rate of prostate cancer was 21.43%(45/210),comparison between groups was not statistically significant(P>0.05);The detection rates of prostate cancer in patients with positive and negative prostate ultrasound were 26.45%(32/121)and 19.01%(23/121),comparison between groups was not statistically significant(P>0.05);The detection rates of prostate cancer in patients with positive and negative prostate MRI were 27.43%(48/175)and 10.45%(7/67),comparison between groups was statistically significant(P<0.05).According to the multivariate Logistics regression analysis : age(P=0.021)?F/TPSA(P=0.043)?PSAD(P=0.000)?(F/TPSA)/PSAD(P=0.000)?MRI(P=0.020)and prostate biopsy pathology department was significantly positive correlation.The order of close contact between each exposure factor and prostate puncture positivity is PSAD>MRI>(F/TPSA)/PSAD>age>F/TPSA;TPSA(P=0.071),digital rectal examination results(P=0.351),ultrasound(P=0.549)and prostate biopsy pathology department was no significantly positive correlation.The area under the ROC curve(AUC)of each indicator is arranged from large to small is:(F/TPSA)/PSAD > PSAD > F/TPSA > MRI >age>ultrasonography> DRE > TPSA.Conclusion:PSAD?F/TPSA?(F/TPSA)/PSAD?MRI and age is a good predictor of prostate puncture results,and ultrasonography?DRE and TPSA has no significant correlation with puncture results.