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Changes Of Blood Cell Parameters In Patients With Acute Myocardial Infarction And Their Value In Diagnosis And Prognosis

Posted on:2020-12-20Degree:MasterType:Thesis
Country:ChinaCandidate:K LuFull Text:PDF
GTID:2404330575493427Subject:Internal medicine
Abstract/Summary:PDF Full Text Request
Objective:To investigate the incidence and prognosis of patients with acute myocardial infarction(AMI)and the classification and counting of white blood cells and their subtypes,red blood cells and their related classification counts,platelets and their related classification,neutrophil/lymphocyte ratio,platelet/lymphocyte ratio and other blood routine indicators.Methods:Collect 403 patients with acute chest pain who underwent coronary intervention at the chest pain center of our hospital from September 2016 to April 2018 were selected as subjects of this study.The venous blood was used as the standard for the first time,and the medical history of the subjects was recorded.,age and other relevant data.According to the final discharge/death diagnosis,they were divided into acute myocardial infarction group(n=268)and non-acute myocardial infarction group(n=135),and the differences between the two groups were analyzed and compared.Results:1.Smoking history,diabetes history,MACE,white blood cell count,neutrophil count,lymphocyte count,neutrophil/lymphocyte ratio(NLR),platelet count,and platelet/lymphocyte ratio(PLR)in the AMI group Higher than non-AMI group(P<0.05);red blood cell distribution width was lower than non-AMI group(P<0.05);gender ratio,age,body mass index,hospital admission heart rate,hypertension history,hyperlipidemia And the conventional indicators of residual blood have no statistical significance,P>0.05.2.Multivariate logistic regression analysis showed:NLR(odds ratio 2.199,95%confidence interval:1.128-4.286,P<0.05)and PLR(odds ratio 3.460,95%confidence interval:1.738-6.890,P<0.001)An independent risk factor for AMI.3.By plotting the ROC curve for AMI based on NLR,PLR and the combination of the two,the area under the curve of NLR is 0.64,95%CI:0.591-0.687,P<0.001,when the NLR cutoff is 3.67,the AMI is diagnosed at this time.The value is higher.The area under the curve of the PLR was 0.62,95%CI:0.571-0.668,P<0.001.When the PLR cutoff was 108.38,the value of the diagnosed AMI was higher.The sensitivity of the parallel test combined with NLR and PLR for the diagnosis of AMI was 70.90,and the specificity was 57.04.4.By plotting the ROC curve for MACE for NLR,PLR and both,the area under the curve of NLR is 0.728,95%CI:0.681-0.771,P<0.001.When it is greater than 6.6,the predicted MACE value is the highest.The area under the curve of PLR is 0.807,95%CI:0.765-0.844,P<0.001.When it is greater than 192,it has the highest predicted MACE value.The sensitivity of the combined prediction of MACE using NLR and PLR is 65.74,and the specificity is 84.75.Conclusion:1.RDW,PLT,WBC,GR and LY have a correlation with AMI,and have certain predictive value for the onset of AMI;2.NLR and PLR are independent risk factors for AMI diagnosis.NLR and PLR are independent risk factors for MACE within 30 days of AMI patients.They can be used as indicators for diagnosing AMI and predicting MACE within 30 days,but there is no obvious advantage.
Keywords/Search Tags:blood routine, acute myocardial infarction, logistic regression analysis, ROC curve
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