Clinical Significance Of Plasma Homocysteine Level In Patients With Acute Cerebral Infarction

BackgroudAcute cerebral infarction(ACI)is a kind of disease that seriously endangers human health.In addition to the traditional risk factors,there are also some non-traditional risk factors,such as Homocysteine(Hcy).Besides traditional risk factors,there are also some non-traditional risk factors.Hcy,for example,is a risk factor for acute cerebral infarction.The severity of stroke,prognosis,etiological classification of recurrence were correlated with high snow level of cysteine.At present,there are few studies on the influence mechanism of Hcy on cerebral apoplexy,and the specific mechanism has not been mastered.Therefore,it is of great clinical value to study the level of Hcy in patients with acute cerebral infarction.PurposesTo explore the significance and influencing factors of plasma homocysteine level in patients with acute cerebral infarction.Methods1.In this study,patients with acute cerebral infarction admitted to the Department of Neurology of a hospital in Xuchang from June 2017 to June 2018 were selected as the subjects.TOAST was used for pathological classification of acute cerebral infarction.2.The evaluation of neurological deficits in all patients was performed using the NIHSS scale,which was evaluated separately at the time of admission and discharge.The relevant research indicators including homocysteine(Hcy),folic acid,and vitamin(VB12)were also tested in all patients.3.The detection time was within 48 hours after admission,the detection method was fasting elbow venous blood,and carotid ultrasound evaluation.4.To compare the relationship between Hcy level and gender,age,etiological classification and severity of cerebral infarction.Results1.A total of 172 patients were enrolled.The comparison of clinical characteristics between the normal group and the high-level group showed that gender,age,hypertension,diabetes mellitus,smoking history and drinking history were risk factors for cerebral infarction.2.The levels of systolic blood pressure,low density lipoprotein,triglyceride,cholesterol and homocysteine in the case group were significantly higher than those in the control group,while the levels of the other three indicators were contrary.3.The level of plasma homocysteine in LAA group was significantly higher than that in CE group,SAO group and other causes group(P=0.012),but there was no significant difference among CE group,SAO group and other causes groups(P>0.05).4.The homocysteine level of patients with NIHSS score less than 7 at admission and discharge was compared with that of patients with NIHSS score greater than or equal to 7.The homocysteine level of patients with NIHSS score greater than or equal to 7 was higher than that of patients with NIHSS score less than 7(P < 0.05).ConclusionThe level of plasma Hcy increased in patients with acute cerebral infarction,especially in patients with severe neurological impairment and death and patients with LAA.Early detection of plasma Hcy level in patients with cerebral infarction is helpful to the diagnosis of etiology subtypes of cerebral infarction,especially LAA,as well as to the judgment of severity and prognosis of stroke patients?...