Study On The Prevalence And Risk Factors Of Chronic Obstructive Pulmonary Disease With Repression

BackgroundChronic obstructive pulmonary disease(COPD)is a disease characterized by airway inflammation and airway remodeling,with inflammatory mediators and various cellular mechanisms involved.In China,the prevalence of COPD in people over 40 years old is 9.9%,and the prevalence increased with the age.COPD tends to be associated with a variety of extrapulmonary diseases,among which depression is one of the most common comorbidities in mental diseases.To the COPD patients,depression severely affects the quality of life and increases the risk of death.ObjectiveTo explore the prevalence and risk factors of COPD patients complicated with depression.Deep screening of risk factors will hlelp establish a more optimized screening index system and guide multidisciplinary clinical treatment for COPD patients with depression.MethodsIn this study,we collected the outpatients with stable COPD and the health examination patients with normal lung function during the same period in our hospital from May 2017 to May 2018.The Hamilton Depression Scale(HAMD)was used to understand the status in all of the patients.Basic data were collected,such as age,gender,working status,marital status,education level,and so on.Lung function was measured in all of the patients.Assess the quality of life and the degree of dyspnea in patients with COPD.To analyze the influence of different factors on the degree of depression and the prevalence of depression in patients with COPD,univariate binary logistic regression analysis was used to screen significant variables,and multivariate binary logistic regression analysis was used to screen risk factors.Results(1)The basic data showed no statistical difference in the COPD group(177 cases)and the non-COPD group(175 cases)and had comparability(P > 0.05).The prevalence of depression in COPD group was higher than that in the non-COPD group(t=11.920,P=0.001).(2)To the COPD patients,smokers(more than 400 cigarettes per year),high education(junior high school and above),poor quality of life,Long-term oxygen therapy patients and caregivers in depression may be have higher depression scores(P < 0.05)and higher prevalence of depression(P < 0.05).(3)To the COPD patients,smoking(> 400 cigarettes/year)increased the risk of depression by 2.088 times compared with smoking(< 400 cigarettes/year).(OR=2.088,95%CI:1.085-4.017).Long-term oxygen therapy increased the risk of depression by 2.249 times compared with non-long-term oxygen therapy(OR=2.249,95%CI :1.090-4.639).Caregivers with depression increased the risk of depression in COPD patients by 2.625 times compared with caregivers without depression(OR=2.625,95%CI: 1.326-5.198).Compared with CAT(Level 1),the CAT(Level 2)increased the risk of depression by 4.224 times(OR=4.224,95%CI: 1.449-12.319).The CAT(Level 3)increased the risk of depression by 4.520 times(OR=4.520,95%CI: 1.522-13.423),The CAT(Level 4)increased the risk of depression by 8.858 times(OR=8.858,95%CI: 2.476-31.690).ConclusionThe prevalence of depression in COPD patients is higher than that in the general population.Heterogeneity exists in COPD patients with depression,COPD patients with different characteristics have different effects on the incidence and degree of depression.Smoking,long-term oxygen therapy,depression in caregivers,and decreased quality of life are risk factors for depression in COPD patients.Patients with COPD have a reduced quality of life and the risk of depression increased.