Clinical Significance Of Preoperative LMR And FIB In Moderately Differentiated Colorectal Adenocarcinoma Patients

Background and Objective: According to the epidemiological survey,the incidence and mortality of colorectal cancer in China have increased,accounting for 5th of the total number of cancer,among which the most common types are moderately differentiated colorectal adenocarcinoma.While the development of endoscopic and imaging is to a certain extent improve the early diagnostic rate of patients with colorectal cancer,it is not ideal for the improvement of the early diagnostic rate and the assessment of the progress of the pre-operative disease.In the early stage,it was confirmed that the ratio of lymphocyte to mononuclear cells(LMR)and fibrinogen(FIB)played an important role in the diagnosis of malignant tumor,the determination of lymph node metastasis,distant metastasis,invasion depth and prognosis.In this paper,the role of FIB and LMR in the moderately differentiated colorectal adenocarcinoma has not been observed in China.The purpose of this study is to study the value of the pre-operative LMR and FIB in the diagnosis of colorectal carcinoma and the pre-operation assessment,and to provide reference for clinical diagnosis and treatment.Methods: A total of 100 patients with moderately differentiated colorectal adenocarcinoma were collected from the first people undefined Hospital of Hefei and Binhu Hospital of Hefei,Anhui Province,from January 2010 to July 2013 as observation group and 50 healthy persons in the same period as control group.The LMR,FIB values of group A and group B were compared.The optimal cut-off value of LMR and FIB in moderately differentiated colorectal cancer patients was determined by the receiver operating characteristic curve.According to the optimal cut-off value,they were divided into high,low LMR,high and low FIB groups.To analyze the relationshipbetween LMR,FIB and clinical features and 5-year survival rate in patients with moderately differentiated colorectal cancer.Results: The LMR of group A(3.39 ±1.48)was lower than that of group B(5.27 ±0.98),the FIB of group A(3.63 ±0.60)g / L was significantly higher than that of group B(2.78±0.41)g / L(P < 0.01).The best cut-off value of LMR,FIB was 3.65,3.495 g / L,respectively.The distant metastasis rate of high LMR group(4.65%)was lower than that of low LMR group(21.05%).The rate of high LMR group in stage ?-?(44.19%)was significantly lower than that of low LMR group(64.91%)(P < 0 05).The distant metastasis rate of high FIB group(22.22%)was higher than that of low FIB group(4.35%).The rate of high FIB group in ?-? group(66.67%)was higher than that of low FIB group(43.48%).The lymph node metastasis rate in high FIB group(59.26%)was significantly higher than that in low FIB group(34.78%)(P<0.05).The 5-year survival rate of high LMR group(76.74%)was higher than that of low LMR group(47.37%).The 5-year survival rate of low FIB group(78.26%)was higher than that of high FIB group(44.44%),the difference was statistically significant(P < 0.01).Conclusion: Preoperative LMR,FIB is valuable in the Auxiliary diagnosis and preoperative evaluation of moderately differentiated colorectal adenocarcinoma.