| Background: Mycoplasma pneumoniae infection can occur in all ages.It was thought to occur mostly in school-age children and adolescents.In recent years,with the improvement of detection methods of mycoplasma pneumoniae,the prevalence of pre-school children and infants has gradually increased.Mycoplasma pneumoniae infection can cause popularity,mainly in closed places such as schools and playgrounds.Mycoplasma pneumoniae infection can occur throughout the year,the incidence of mycoplasma pneumoniae pneumonia was relatively high in winter and spring in the north while was high in summer and autumn in the south,because different regions have the different suitable environment for the growth of mycoplasma pneumoniae.Mycoplasma pneumoniae infection can cause acute pharyngitis,tonsillitis,pneumonia and so on.With the increase of macrolide-resistance mycoplasma pneumoniae,the incidence of refractory mycoplasma pneumoniae pneumonia is increasing year by year.If it is not treated promptly or treat inappropriatetly,it will develop into severe mycoplasma pneumoniae pneumonia,which present with severe pulmonary and extrapulmonary manifestations.When severely infected,hypoxia and pathogenic microorganisms release toxins,inflammatory factors and other factors can damage vascular endothelial cells,then activate endogenous and exogenous coagulation pathways,triggering coagulopathy,and even multiple organ dysfunction.Since 1991,Creagh et al reported a case of mycoplasma pneumoniae pneumonia complicated with femoral vein thrombosis,there have been many reports of mycoplasma pneumoniae pneumonia complicated with organ infarction or thrombosis at home and abroad,involving retinal artery,middle cerebral artery,right ventricle,deep veins etc.Patients with organ infarction or thrombosis are closely related to the severity and prognosis of the disease,so it is especially important for clinicians to screen early for possible organ embolism or thrombosis.Objectives: By analyzing the changes of D-D,PLT,PT,APTT and FIB in children with mild mycoplasma pneumoniae pneumonia and severe mycoplasma pneumoniae pneumonia,the early diagnostic value of these indicators for severe mycoplasma pneumoniae pneumonia in children with hypercoagulable state was discussed.Methods: A study was conducted on children diagnosed with mycoplasma pneumoniae pneumonia in Department of Pediatrics,The First Hospital of Jilin University from January 2017 to February 2019.The male and female ratios were equal.They were divided into two groups including the mild mycoplasma pneumoniae pneumonia and the severe mycoplasma pneumoniae pneumonia,every group include 44 cases.The study was approved by the ethics committee of the hospital and obtained informed consent from the parents before the subjects were selected.Results:(1)There was no significant difference in age and gender between severe mycoplasma pneumoniae pneumonia group and mild mycoplasma pneumoniae pneumonia(P>0.05).(2)D-D and FIB levels in severe mycoplasma pneumoniae pneumonia group were significantly higher than those in mild mycoplasma pneumoniae pneumonia group,the PLT was lower than the mild mycoplasma pneumoniae pneumonia group,and the APTT and PT were prolonged compared with the mild mycoplasma pneumoniae pneumonia group(P<0.05).(3)The D-D of severe mycoplasma pneumoniae pneumonia was positively correlated with the percentage of neutrophils(r=0.420,P=0.005)and LDH(r=0.539,P=0.000),and there was no clear correlation between D-D and prealbumin(r=-0.209,P=0.17);There was no correlation between D-D and neutrophil percentage,LDH and prealbumin in the mild mycoplasma pneumoniae pneumonia group(P>0.05).Conclusion:(1)Elevated D-D and FIB in children with severe mycoplasmal pneumoniae suggest a hypercoagulable state.(2)There was no significant correlation between APTT,PT and PLT in children with severe pneumonia mycoplasma pneumonia.(3)Joint analysis of D-D,neutrophil percentage,and LDH are more meaningful for the assessment of the condition of children with pneumonia mycoplasma pneumonia. |
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