Clinical Observation Of Jingfangsiwu Decoction Combined With EGFR Targeting Drug Gefitinib In The Treatment Of Advanced Non-small Cell Lung Cancer

Lung cancer is a disease with a very high mortality rate.The world health organization(WHO)announced it as one of the top ten causes of human death in 2018 [1].With the continuous research,its mainstream treatment has developed from optimal supportive treatment to targeted treatment,and substantial progress has been made in efficacy [2].About 70 percent of patients are in the advanced stages of diagnosis.For patients with advanced non-small cell lung cancer with confirmed gene mutations,clinical guidelines generally recommend targeted therapy with oral tyrosine kinase inhibitors(TKIs)[3].However,in the process of targeted drug treatment,side effects such as skin rash are likely to occur,resulting in poor tolerance,poor compliance and even termination of treatment.However,at the same time,relevant studies have also shown that the effective rate of patients with lung cancer and the duration of disease progression are closely related to the incidence of these adverse skin reactions and the degree of inflammation [4].The conflict between clinical efficacy and adverse drug reactions has become a thorny issue in clinical work.Traditional Chinese medicine(TCM)is a summary of the experienceof ancient Chinese medical workers in long-term treatment of diseases,and it has its unique insights into the prevention,diagnosis and treatment of diseases and related work [5].A large number of studies believe that traditional Chinese medicine can improve patients' physique and enhance their immunity,while western medicine directly ACTS on cancer cells and promotes their apoptosis.If they can be used together,whether they can achieve the purpose of increasing efficiency and reducing toxicity [6].Traditional Chinese medicine has its unique insights into the study of skin diseases,especially skin rashes.According to the manifestations of different syndromes,treatment based on syndrome differentiation and prescription application can significantly improve the subjective symptoms of patients and improve the quality of life [7].Therefore,this clinical observation was designed to explore the short-term efficacy of traditional Chinese medicine prescription combined with targeted drugs in the treatment of advanced non-small cell lung cancer(NSCLC),as well as the effect on improving patients' quality of life,alleviating related adverse reactions and enhancing safety.[objective] to observe the short-term efficacy of jingfangsiwu decoction combined with egfr-targeted drug gefitinib in the treatment of patients with advanced non-small cell lung cancer,its effect on their quality of life,rash occurrence,skin infection,hospitalization due to side effects and other aspects,and to evaluate the safety of gefitinib and other studies.[method] according to certain diagnosis,and exclusion criteria,in wuhan city center hospital patients,collected in January 2016 to January 2019,three years of 60 cases,all patientsinto the observation the treatment to take tablets,the treatment group cooperate with traditional Chinese medicine syndrome differentiation treatment,mainly according to jing siwu tonga subtraction,decoct soup oral,a dose of 1 week for a period of treatment,even served 16 after treatment,using its own comparison and contrast between groups,short-term curative effect on the evaluation of patients before and after the treatment,the influence of the quality of life situation,skin infections occur,rash and hospitalization due to side effects,The safety of gefitinib and other studies were evaluated.[results] the clinical observation participants included60 patients,the entire research process with no exit and loss,all can participate in the evaluation of curative effect,in the treatment group 30 cases,complete remission(CR)to 0 cases(0%)and partial response(PR)in 14 cases(46.67%),stable disease(SD)for 11 cases(36.67%),disease progression(PD)for 6 cases(20%),effective rate was 46.6%;Among the 30 cases in the control group,0 cases(0%)had complete response(CR),12 cases(40%)had partial response(PR),12 cases(40%)had stable disease(SD),6 cases(20%)had disease progression(PD),and the effective rate was 40%.[conclusion] the thorn siwu decoction combined EGFR the treatment targeted drugs treatment of advanced non-small cell lung cancer in the near future curative effect,the treatment with pure EGFR targeted drugs group clinical short-term curative effect,but can effectively improve the patient's quality of life,control the incidence of rash,skin infections and reduce hospitalization happen due to side effects,and good clinical confirmed its safety.