| Objective:(1)To investigate the possible pathogenic factors of patients with premature ovarian insufficiency of kidney-deficiency and liver-stagnation type through questionnaire,and make statistical analysis;(2)By observing Bushenshugan decoction combined acupuncture and Bushenshugan decoction treatment kidney liver depression type of premature ovarian insufficiency clinical curative effects,using statistical analysis software,compares and analysis,the overall clinical efficacy for clinical treatment of premature ovarian insufficiency provide effective treatments provide certain ideas and related research work.Method:Collected from March 2017 to December 2018 to the traditional Chinese garden mountain in hubei province department of gynaecology clinic,conform to the inclusion criteria were diagnosed with kidney liver depression in patients withpremature ovarian insufficiency 62 cases of group into each patient before the experiment investigation,psychological stress factors were randomly divided into needle medicine and Chinese medicine group,each group of 31 cases,needle medicine group was treated with Bushenshugan decoction combined acupuncture and Chinese medicine group with Bushenshugan decoction treatment,treatment of three consecutive menstrual cycles and then observed before and after treatment in patients with TCM syndrome integral,Changes in serum FSH,LH,E2 and AMH,endometrial thickness,and overall efficacy.Results:(1)The enrolled patients were mainly aged between 32 and 39 years old,who had been stimulated by negative sexual life events(especially family discord or marital problems,financial pressure),and had different negative emotions(among which,distress,depression and anxiety were over 50%,and there were multiple negative emotions).The results suggest that the patients with premature ovarian insufficiency of kidney deficiency and liver depression may have different psychosocial problems.(2)Comparison of TCM syndrome points: the scores of hyposexuality and dizziness and tinnitus in the acupuncture group were all greater than 0.05,with no statistical significance;the scores of other syndromes were all less than0.01,with statistically significant differences.The scores of hyposexuality,mental depression,dizziness,tinnitus,insomnia and multiple dreams in the traditional Chinese medicine group were compared by P > 0.05,and the differences were not statistically significant.The scores of other syndromes were all less than 0.01,and the differences were statistically significant.After treatment,the scores of depression,irritability,chest tightness,insomnia and multiple dreams were compared between the two groups,with P value less than 0.01,and the differences were statistically significant.The scores of other syndromes were all greater than 0.05,and the differences were not statistically significant.The results showed that both the acupuncture group and the traditional Chinese medicine group could improve the clinical symptoms of patients with premature ovarian insufficiency of kidney-deficiency and liver-stagnation type,but the symptoms of decreased libido and dizziness and tinnitus were not significantly improved.The effect of acupuncture group was better than that of TCM group in improving TCM syndrome.(3)Comparison of sex hormones(FSH,LH,E2),AMH and endometrial thickness: before and after treatment,P values of patients in the acupuncture group and the traditional Chinese medicine group were all less than 0.01,with statistically significant differences.After treatment,P value of the two groups was greater than 0.05,and the difference was not statistically significant.Results indicate: the needle medicine and Chinese medicine group could increase serum E2,AMH level,lower levels of serum FSH,LH,increase the endometrial thickness,type of kidney liver depression premature ovarian insufficiency is not complete effective treatment,but the two groups in the elevated serum E2,AMH level,lower levels of serum FSH,LH,increased endometrial thickness has no obvious differences.(4)Comparison of total efficacy: after treatment,the total effective rates of the acupuncture group and the traditional Chinese medicine group were87.10% and 70.98%,respectively.The result indicated: the acupuncture medicine group total curative effect is superior to the traditional Chinese medicine group.Conclusion:The results of this study show that :(1)the pathogenesis of premature ovarian insufficiency of kidney deficiency and liver depression type may be related to social psychological stress;(2)Bushenshugan decoction combined with acupuncture and Bushenshugan decoction were both effective in the treatment of premature ovarian insufficiency of kidney-deficiency and liver-stagnation type,both of which could improve some clinical symptoms of the patients,among which the combination of acupuncture and drug therapy was significantly better than the traditional Chinese medicine group in improving mental depression,irritability,chest tightness and insomnia.Both bushenshugan decoction combined with acupuncture and bushenshugan decoction can regulate the serum sex hormone levels(lower serum FSH and LH levels and higher serum E2 levels),increase serum AMH levels and increase endometrial thickness in patients with premature ovarian insufficiency of kidney-deficiency and liver-stagnation type,but there is no significant difference between the two groups in regulating the above indexes.Comparing the total curative effect,the curative effect of acupuncture and drug combination on premature ovarian insufficiency of kidney deficiency and liver depression type is better than that of traditional Chinese medicine group alone. |
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