The Value Of CA125 Combined LMR In The Diagnosis Of Ovarian Cancer

Objectives Ovarian cancer is the third most common malignancy in the female reproductive system,but the mortality rate is the highest in gynecological tumors,and is the main cause of death of malignant tumor in female reproductive system.The screening of ovarian cancer mainly depends on the detection of serum tumor markers and imaging examination,but due to the high technical requirements and cost high,the penetration rate is low.The purpose of this study was to explore the value of CA125 combined LMR in the diagnosis of ovarian cancer and the application of LMR in the differential diagnosis of ovarian mass.Methods The patients who were admitted to our hospital from January 2017 to December 2017 were selected.All subjects improved blood routine detection and serum tumor markers(CA125 and HE4)within 7 days before surgery.According to the clinical diagnosis,the patients were divided into 63 patients with ovarian cancer group,72 patients with benign ovarian tumor group,and 57 patients with healthy control group.The three groups of patients were analyzed to clarify the role of LMR in the diagnosis of ovarian cancer.The patients who underwent surgical treatment of ovarian masses(28 cases of ovarian cancer and 39 cases of benign ovarian tumors)were analyzed for their CA125,HE4,pathological diagnosis and blood routine examination and find out the correlation between LMR and clinical pathological stage,pathological type,CA125 level and HE41evelMeanwhile,calculate the NLR and PLR NLR,PLR computing patient at the same time,application of Logistic regression model respectively,calculate the CA125,CA125 + HE4 and CA125 + PLR,CA125 + NLR,CA125 + MLR predicted value of diagnosis of ovarian cancer,and application of ROC analysis,clear the above combination sensitivity in the diagnosis of ovarian cancer.Results The LMR mean of ovarian cancer group was lower than that of the benign tumor group and healthy control group,and the area under the ROC curve was greater than 0.5(0.721,P=0.011;0.842,P<0.001).The cut-off value was 3.993 and 4.761,respectively.That is,in patients with ovarian mass,LMR<3.993,the possibility of malignancy is high;When screening for ovarian cancer,CA125 levels are elevated and LMR<4.761 should be alert to ovarian lesions.In the correlation analysis of pathological types of LMR and ovarian cancer patients,the area under the ROC curve was 0.764,cut-off 4.79,P=0.037<0.05.The chi-square test indicated that the difference between high LMR(>3.993)and low LMR(no less than 3.993)was statistically significant(P=0.000<0.01).However,the correlation between LMR and the clinical stage of ovarian cancer was not clear,and the area under the curve was 0.558,cut-off 6.73,P=0.0589>0.05.CA125+LMR is the most sensitive index after CA125+HE4 in the diagnosis of ovarian and ovarian cancer screening with CA125 and HE4,LMR,NLR and PLR.Conclusions CA125 combined with LMR diagnosis of ovarian cancer was more accurate;LMR is of great significance in the screening of ovarian cancer and the benign and malignant differentiation of ovarian neoplasms.