Influencing Factors And Treatment Progress Of Hemorrhagic Cystitis After Hematopoietic Stem Cell Transplantation

Objective:Hematopoietic stem cell transplantation(HSCT)has been widely used in the treatment of hematological diseases as a mature therapy.Hemorrhagic cystitis,as a common and important complication after transplantation,often leads to a decline in the quality of life and prolonged hospital stay.Severe cases can cause obstructive renal failure,or even life-threatening.In this study,on one hand,the risk factors of hemorrhagic cystitis after hematopoietic stem cell transplantation(HSCT)were discussed,and early diagnosis and intervention could improve the quality of life and prognosis of the patients.On the other hand,the treatment of hemorrhagic cystitis was discussed.To guide the clinical work.Methods:The data of 241 patients undergoing hematopoietic stem cell transplantation in Qianfoshan Hospital of Shandong Province from July 2011 to February 2018 were retrospectively analyzed.1.Select 8clinical parameters:sex,age,risk factor stratification,graft source,acute graft versus host disease(aGVHD),pretreatment scheme?CMV infection,BK virus urine for single factor risk analysis.The significant factors hanging from single factor analysis were analyzed by Logistic regression.2.Hydration,alkalization,diuresis,antivirus,methylprednisolone and bladder irrigation are given to patients with HC,and the clinical effects obtained are observed.Results:1.46 patients(19.09%)developed HC,including 20 patients(43.48%)of degree ?,17 patients(36.96%)of degree ?,7 patients(15.22%)of degree iii,2 patients(4.34%)of degree ?,onset time +9-+85d(noon time +25d),duration 4-61d(median duration 9.6d).univariate analysis showed that pretreatment with CTX,aGVHD?CMV infection and BK virus urine were related to the occurrence of HC(p<0.05).Multivariate analysis found that only BK virus urine was statistically correlated with HC.2.46 cases of HC patients after clinical treatment,32 cases were significantly effective,14 cases were effective,the total effective rate was 100%.Conclusion:1.Hemorrhagic cystitis is an important complication after hematopoietic stem cell transplantation.BK virus urine is independent risk factors for hemorrhagic cystitis.2.Local treatment of bladder,anti-virus,immunosuppressants,mesenchymal stem cells and interventional therapy are commonly used in clinical treatment of hemorrhagic cystitis,and specific treatment should be given in combination with the actual situation of patients in clinical treatment.