Clinical Features Of Patients With Alcoholic Liver Disease

Objective: To study the clinical features of Alcoholic Liver Disease(ALD)for the diagnosis and treatment of ALD.Methods: According to the guideline,the clinical data of 204 patients with ALD were retrospectively analyzed from January 2010 to June 2018 in Shandong Provincial Hospital.At the same time,85 cases with hepatitis B cirrhosis were enrolled.Results: Among 204 cases of ALD patients,there were 5 cases of alcoholic fatty liver(AFL),32 cases of alcoholic hepatitis(AH)and 167 cases of alcoholic cirrhosis(AC);the average age was(52.19±10.33)years old.The patients with age between 40 and 59 took up 63.33%.The mean age of AC patients was(52.86±9.74)years,which was obviously elder than those of AFL and AH patients(P<0.05).The proportions of farmers and workers were 44.12% and 19.61%,respectively.The daily alcohol consumption volume with cirrhosis patients was(162.41±91.06)g and the drinking history was(27.05±9.63)years,which were apparently higher than those of AFL and AH patients.The most common clinical symptoms among ALD patients was abdominal distension(52.9%),and the most common physical sign was associated with ascites(49.51%).The common complications included infection,primary hepatic carcinoma(PHC)and hepatic encephalopathy(HE)etc.The highest incidence of hepatocellular carcinoma was found in patients with compensatory cirrhosis(43.48%).The abnormal AST level(84%)of ALD patients was apparently higher than ALT(33.33%)(P<0.05).In addition,the GGT level and AST/ALT in AC patients were significantly higher than those in Patients with hepatitis B cirrhosis(P>0.05).The blood ammonia in patients with HE and patients with non-HE were(115.14±44.68)?mol/L and(85.52±32.23)?mol/L respectively(P<0.05).The incidence of death?peritonitis?hepatorenal syndrome and hepatic encephalopathy were obviously increased in patients whose Maddrey was greater than 32.A big difference was discovered between liver cirrhosis patients and no cirrhosis patients in FIB-4 and APRI.Conclusions: The majority of ALD patients were middle aged male patients.The injury degree of liver and the evolvement of ALD were associated with the total consumption of alcohol.Infection,primary liver cancer and hepatic encephalopathy were the common complications of ALD patients,which were closely related to prognosis.GGT and AST/ALT elevation are specific serological features of ALD.FIB-4 index was a suitable model for evaluating the existence of liver cirrhosis.Maddrey?s discriminant function is an ideal index for evaluating the mortality and the incidence rate of complications in ALD patients.