Clinical Research Of Yiqishuxuetongmai Prescription On Patients With Cognitive Impairment After Ischemic Stroke Of Qi Deficiency And Sputum Stasis

Objective: To observe the clinical efficacy and safety of Yiqishuxuetongmai prescription on patients with cognitive impairment no dementia after ischemic stroke of Qi deficiency and sputum stasis.Method: Sixty patients with cognitive impairment no dementia after ischemic stroke of Qi deficiency and sputum stasis were enrolled into the observation group and the control group by setting random numbers through statistical software,and each group are 30 patients is treated with appropriate treatment for 3 months and followed up after 6 months.The patients in both groups were treated with basic therapy.The observation group was treated with Yiqishuxuetongmai prescription and donepezil hydrochloride tablets.The control group was treated with donepezil hydrochloride tablets.And MoCA,TMTA-B,AVLT,CDT and P300 examination were performed before intervention,at 2 weeks,1 month,and 3 months after intervention and 6 months after follow-up.Before and after treatment,routine chemical examinations were monitored in the two groups,and adverse reactions were recorded.Result:(1)MoCA scores: The score at 3 months after treatment,6 months after follow-up had statistically significant difference compared with that before treatment in the two groups(P < 0.01).And there was statistical difference between the two groups during that time(P<0.05).The curative effect of the observation group was better than the control group.(2)Event-related potential P300 detection: P300 incubation period and amplitude at 1 month,3 months after treatment and 6 months after follow-up had statistically significant difference compared with that before treatment in the two groups(P < 0.01).There was statistical difference in P300 incubation period and amplitude between the two groups at 1 month,3 months after treatment and 6 months after follow-up(P < 0.05).(3)TMTA-B results: The completion time of TMTA-B at 3 months after treatment,6 months after follow-up had statistically significant difference compared with that before treatment in the two groups(P < 0.01).The completion time of TMTA was statistically different between the two groups at 3 months after treatment and 6 months after follow-up(P < 0.05).After 3 months of treatment,the TMTB partial completion time of the two groups showed significant statistical difference(P < 0.01),while the comparison of the two groups at 6 months of follow-up showed statistical difference(P < 0.05).(4)AVLT results: The short-term memory and delayed recall at 3 months after treatment and 6 months after follow-up had statistically significant difference compared with that before treatment in the two groups(P < 0.01).The delayed recognition showed significant statistical difference between 3 months after treatment and that before treatment in the two groups(P < 0.01),while the comparison at 6 months after follow-up and that before treatment showed statistical difference(P < 0.05).After 3 months of treatment,there was statistical difference in short-term memory and delayed recall between the two groups(P < 0.05).At 6 months of follow-up,there was statistical difference in the delayed recognition between the two groups(P < 0.05).(5)CDT scores: The score had statistically significant difference at 3 months after treatment and 6 months after follow-up compared with that before treatment in the the observation group(P < 0.01).The score had statistical difference between the two groups at 3 months after treatment and 6 months after follow-up(P<0.05).(6)There were no obvious abnormalities in routine chemical examination results before and after treatment in the two groups,and no serious adverse reactions were observed.Conclusion: Yiqishuxuetongmai prescription could significantly improve the global cognitive,executive ability,memory,visuospatial ability with cognitive impairment no dementia after ischemic stroke of Qi deficiency and sputum stasis patients.The application of Yiqishuxuetongmai prescription is safe and reliable.