Association Of Glycated Serum Protein Level With The Prevalence And Severity Of Coronary Artery Disease

Objective: To analyze the relationship between glycosylated serum protein level and blood lipid,coronary heart disease and severity of coronary artery disease.Methods: 1449 patients with suspected coronary heart disease underwent coronary angiography from January 2018 to October 2018 in the Department of General Cardiology of our hospital were selected,and the severity of coronary artery disease was evaluated with Gensini score index.According to the results of coronary angiography and whether diabetes has been diagnosed before or newly diagnosed after admission,they are divided into control group,simple coronary heart disease group and coronary heart disease complicated with diabetes group.354 cases are included in the control group,802 cases are included in the coronary heart disease group and 293 cases are included in the coronary heart disease complicated with diabetes group.The general data,biochemical indexes and coronary angiography results of the subjects were collected to analyze the risk factors related to coronary heart disease and severity of coronary artery disease.Results:(1)There were significant differences in age,FBG,GSP,TG,TC,LDL,HDL,Gensini score among the three groups(P<0.001).The GSP,TG,Gensini score of CHD complicated with diabetes were higher than those of CHD group and control group,and the differences were statistically significant(P<0.05).(2)The subjects in each group were further divided into two groups according to GSP level.the comparison showed that the differences of TG,TC,LDL,HDL,LDL/HDL,TC/HDL between normal GSP and High GSP in coronary heart disease combined with diabetes group were statistically significant(P<0.05),among which TG,TC,LDL,LDL/HDL,TC/HDL of normal GSP were lower than High GSP and HDL was higher than High GSP.(3)Logistic regression analysis showed that GSP was significantly correlated with coronary heart disease(OR=11.556,95% CI5.030~26.550,P<0.001);In coronary heart disease group,GSP has no significant correlation withcoronary heart disease(OR=0.986,95%CI5.030~26.550,P<0.001).(4)The difference between different glycated serum protein levels and Genseni scores among the three groups was statistically significant(P<0.05).Genseni scores in the group with simple coronary heart disease and coronary heart disease combined with diabetes were higher than those in the control group,while Genseni scores in the group with diabetes were higher than those in the group with coronary heart disease.Through ROC curve analysis,the critical value of GSP>2.37 is more sensitive to detect the severity of coronary artery disease in diabetic patients than the critical value of fasting blood glucose>7.93(70.50%vs54.00%).Conclusion: The level of glycosylated serum protein(GSP)is a related risk factor for coronary heart disease and exacerbation of coronary artery disease.