| ObjectiveThe study is to innovate the ways of using Liuwei Dihuang classic prescriptions by make it into ointment rubbing.After that,Liuwei Dihuang ointment was used as a medium in the process of massage therapy for premature low birth weight infants.And then,to further explore the possible mechanism of Action by observe the effect of this ointment on the patient's large motor function.By the way,the purpose is to explore a simple and effective therapy for the development of large motor function in premature low birth weight infants and to lay a foundation for the further clinical promotion.MethodsLiuwei Dihuang ointment is made according to the patent "Plaster for promoting growth and development of premature low birth weight infants and preparation"(patent application number: 201510994773.0),and it's producted in the laboratory of traditional Chinese medicine preparation of Yunnan university of traditional Chinese medicine.With the financial support of the "pre-clinical study of Liuwei Dihuang ointment" project of Yunnan Provincial Health and Health Commission,the ointment's safety experiments of acute toxicity,irritation and skin hypersensitivity were carry out.The 60 preterm low birth weight infants were randomly divided into two groups according to "random number table" method: Test Group(N=30)and Control Group(N=30).The two groups used the same massage method and gave the same feeding,nursing and health care guidance.In the second step of massage manipulation,the test group was added with Liuwei Dihuang ointment sa massage mudium.In the same position,the control group was treated with Johnson's infant nourishing lotion.Each treatment lasts for 30 minutes,Once a day,five days of continuous treatment,rest for 2 days,28 days(4 weeks)as a course of treatment,a total of one course of treatment.Before treatment and after 4 weeks of treatment,the two groups were evaluated by special personnel at the same place on the general situation of the children(gender,age,gestational age,length,weight,head circumference),Symptom score of TCM four dianosis and the function of large movement.The data were analyzed with IBM SPSS 21.0 and Excel software.Results1.General comparisonBefore treatment,there were no significant differences in gender,age,corrected age,gestational age,mode of delivery,birth status,birth length,weight and head circumference between the two groups(P?0.05).The body length changes of the two groups were compared:The test group pre-treatment body length(67.46±5.77)cm,after 4 weeks of treatment body length(70.80±5.66)cm.The difference in body length between the test group before treatment and 4 weeks after treatment was statistically significant(p< 0.01).The control group pre-treatment height(67.81±6.15)cm,after 4 weeks of Treatment Height(69.07±6.02)cm.The difference in body length between the control group before treatment and 4 weeks after treatment was statistically significant(p <0.01).There was no significant difference in body length between the two groups after4 weeks of treatment(P > 0.05).Comparison of Body Weight Change between two groups:The test group body weight before treatment(7.12±1.24),body weight 4 weeks after Treatment(8.34±0.60).The difference in body weight between the test group before treatment and 4 weeks after treatment was statistically significant(p <0.01).The control group body weight before treatment(7.27±0.98),body weight 4weeks after Treatment(7.86±0.88).The difference in body weight between the controlgroup before treatment and 4 weeks after treatment was statistically significant(p <0.01).There was significant difference in body weight between the two groups after 4weeks of treatment(P < 0.05).Comparison of changes of Head circumference between the two groups:Head circumference(42.08±2.28)before treatment and head circumference(44.44±2.44)after 4 weeks of treatment in Test Group.The difference in head circumference between the test group before treatment and 4 weeks after treatment was statistically significant(p < 0.01).Head circumference(41.88±1.95)before treatment and head circumference(43.19±2.06)after 4 weeks of treatment in control group.The difference in head circumference between the control group before treatment and 4 weeks after treatment was statistically significant(p < 0.01).There was significant difference in head circumference between the two groups after 4weeks of treatment(P < 0.05).2.Comparison of symptom score of TCM four dianosis:Before treatment,there were no significant differences in Treatment Score between the two groups(P?0.05).pre-treatment score(36.53±4.03),4 weeks after Treatment Score(43.87±2.56)in test group.The difference in Treatment Score between the test group before treatment and 4 weeks after treatment was statistically significant(p <0.01).pre-treatment score(36.37±3.21),4 weeks after Treatment Score(42.30±3.25)in control group.The difference in Treatment Score between the control group before treatment and 4 weeks after treatment was statistically significant(p < 0.01).The results showed that the symptom scores of TCM four dianosis of the two groups were improved after treatment,and the experimental group was better than the control group.There was significant difference in Treatment Score between the two groups after 4 weeks of treatment(P <0.05).3.Comparison of Major Motor Function Scores:Before treatment,there were no significant differences in AIMS total score between the two groups(P?0.05),and the number of AIMS score ?5% had no significant difference between the two groups(p > 0.05).AIMS total score before treatment(29.17±9.99),AIMS total score after 4 weeks of Treatment(44.67±9.03)in test group.The difference in AIMS total score between the test group before treatment and 4 weeks after treatment was statistically significant(p < 0.01).AIMS total score before treatment(28.40±10.36),AIMS total score after 4 weeks of Treatment(38.57±10.24)in control group.The difference in AIMS total score between the control group before treatment and 4 weeks after treatment was statistically significant(p < 0.01).There was significant difference in total score of AIMS between the two groups 4 weeks after treatment(p < 0.05).The number of AIMS score ?5% before treatment(11),the number of AIMS score ?5% after treatment(2)in test group.the number of AIMS score ?5% before treatment(10),after treatment,the number of AIMS score ?5%(6)in control group.After 4 weeks of treatment,the proportion of AIMS score ?5% was significantly different between the two groups(p < 0.05),which showed that the motor function of the two groups was improved and the proportion of abnormal motor function was decreased The Motor function of the test group was better than that of the control group.4.No adverse reactions were found during the treatment.Conclusions1.Liuwei Dihuang Ointment Massage has the function of promoting the movement development of gross motor function such as raising head,turning over,crawling,sitting,standing and walking of premature low birth weight infants.2.According to the four diagnostic methods of traditional Chinese medicine,Liuwei Dihuang Ointment Massage can improve the constitution and promote the physical development of premature low birth weight infants.3.Liuwei Dihuang Ointment Massage can promoting the physical and gross motor function development of premature low birth weight infants.The mechanism of this treatment may be the combination of massage and medcine,thus playing s dual role.In addition,this treatment method embodies the advantages of external treatment of traditional Chinese medicine.To sum up this method of treatment is worthy of clinical promotion. |
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