| Objective:By observing the clinical effect of Si Si Pai Shi Recipe on renal colic of uric acid calculi,the mechanism of relieving pain and promoting stone removal was studied,and the advantages of traditional Chinese medicine "clearing heat,removing dampness,activating qi and relieving pain" in distinguishing and treating renal colic of uric acid calculi were inherited and developed.Methods:A total of 72 patients with uric acid stone renal colic diagnosed by western medicine within one week before treatment and TCM syndrome of "lower jiao dampness-heat and qi disturbance" were selected and divided into control group and treatment group by stratified random method,including 36 cases in the control group and 36 cases in the treatment group.Among them,patients in the control group were treated with sodium potassium citrate at 10g/ day,and those in the treatment group were given "Si Si Pai Shi"(granules).Both groups were taken 1 hour after breakfast and dinner with 500 ml of warm water.After taking the medicine,they jumped for 10 minutes with a frequency of about 120 times per minute.Patients were instructed to observe their urination every time they urinated.The cut-off point of the study was 2weeks of stone expulsion or medication.If the patient has severe pain in the discharge,diclofenac sodium can be added to both groups for pain relief,no more than 100 mg per day.Observed and recorded in the two groups before and after the treatment of TCM syndrome integral,the changes of renal colic pain(seizure frequency,every time the degree of pain,pain relief time),observed calculi discharge or research review in ending point B to exceed,define the nature of platoon stone(stone rate and length of discharge),while detecting urine red blood cells,urine PH value,the change of blood uric acid.T test was used for count data,X2 test was used for measurement data,and rank sum test was used for rank data.Results:1.72 study patients(4 cases are eliminated because of the pain is difficult to travel,tolerance,so a total of 68 patients were included in),two groups of patients before treatment in the Stone Age,gender,duration,amount,location,the stones size,TCM syndrome integral,urine red blood cells and urine PH,blood uric acid and other indicators,there were no statistically significant difference(P > 0.05),two groups of data are comparable.2.There was no statistically significant difference in the total effective rate between the control group and the treatment group in the treatment of uric acid calculi(P>0.05),and both groups had good effects.3.There was no significant difference in the stone rate between the control group and the treatment group(P>0.05).4.During the two-week observation period,the stone excretion time of the two groups was statistically significant(P<0.05),indicating that the stone excretion time of the treatment group was significantly shorter than that of the control group.5.The changes of renal colic in the two groups were compared,including pain frequency,pain degree and pain relief time.One week after treatment,the incidence of renal colic was compared between the two groups,with 2.09 1.23 in the control group and 2.05 1.37 in the treatment group.The difference was statistically significant(P > 0.05),indicating that the incidence of renal colic was decreased in both groups.By comparing the pain degree of the two groups,the treatment factors F=6.658,P=0.012,P < 0.05,and the time factors F=42.101,P=0.000,P < 0.01,it can be considered that the pain scores of the two groups are different,and the pain scores of the patients at each time point are different or not all equal.Interaction between time and treatment factor F=2.857,P=0.041,it can be considered that there is an interaction between treatment factor and time factor.The pain relief time of the two groups was 4.88 0.98 in the control group and 3.00 0.93 in the treatment group,and the difference was statistically significant(P<0.05),indicating that the pain relief time of the control group was longer than that of the treatment group.6.Urine red blood cells were detected,and the difference was statistically significant(P < 0.05),indicating that the treatment group was superior to the control group in reducing red blood cells.7.Urine PH was detected,and the difference was statistically significant(P<0.05),indicating that the treatment group was superior to the control group in terms of alkalization of urine.8.Uric acid in blood was detected,and the difference was not statistically significant(P>0.05),indicating that there was no significant difference between the two groups.9.TCM syndrome scores of the two groups were compared,and the difference was not statistically significant(P>0.05),indicating that both groups had the effect of improving TCM syndrome.The comparison of the single syndrome points of shenli fatigue,painful urination,chills and cold limbs showed statistically significant differences(P<0.05),indicating that the treatment group was superior to the control group.Conclusion:Sisipaishi Recipe has the same curative effect as the control group in the total effective rate of uric acid calculi renal colic,which has the same effect as the control group in stone removal,but the stone removal time is obviously better than the control group.Sisipaishi recipe is as effective as the control group in alleviating the frequency of renal colic attack,reducing the pain degree of patients and significantly shortening the pain relief time.In terms of test indicators,the prescription also has significant effect in reducing urinary erythrocytes and alkalizing urine.In addition,Sisipaishi,as a recipe with heat-clearing,dampness-removing,qi-relieving and analgesic effects,plays an obvious role in relieving patients' mental fatigue,painful urination and cold chills,which significantly reduces the single TCM syndrome score.However,due to the short time of this study,we cannot determine whether this prescription has an intervention effect on uric acid in blood,which needs further discussion.In a word,Sisipaishi Recipe has significant effect on relieving pain and improving symptoms,which is worthy of further clinical application. |
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