Comparison With Urinary Calculi Chemical Analysis And Its Relationship With Serum Uric Acid Level

Introduction: Urinary calculus is one of the common disease in our country, threatening the health of mankind. Although there were many treatments of urinary calculi, many problems, such as postoperative recurrence, still exist. The targeted medical prophylaxis required reliable information on stone type which when combined with relevant blood and urine analysis allows identification of treatable risk factors.Objective: The exact determination of the compositional structure of the renal stone enables the classification of the disease and its subsequent treatment.Methods: A total of 200 consecutive patients both male and females with upper urinary tract calculi will be included in this study. This is a comparative study between the patients and age matched controls. These patients and controls will have preoperative assessment of serum uric acid. After surgery the chemical examination of stones will be done by chemical methods and infrared spectroscopy.Results: Infrared spectroscopy is obviously better than that of chemical analysis method. The stones of 200 cases with calcium oxalate calculus based, accounting for 73%; followed by phosphate and uric acid stones. The mean serum uric acid in S.F(294.6±52.2) umol/l was greater than N.S.F(227.4±46.8) umol/l and the difference was statistically significant. 24 stones(12%), were uric acid stone, while the rest of stones were of calcium oxalate calculus(73%). In calcium oxalate stones group, blood uric acid level is the highest(319.8±77.4)umol/l compared with the other groups. There were differences in statistical significance. The other three groups of serum uric acid levels were(261.0±61.2)umol/l,(220.8±54.0)umol/l, and(231.6±52.2)umol/l, there was no statistically difference between the groups.Conclusions: Infrared spectroscopy analysis of stone composition can accurately determine the main composition of stones. The level of serum uric acid may be a potential risk factor for urinary tract stones forming in our region. The level of serum uric acid is related to the occurrence of calcium oxalate stone,and a useful indicator to prevention occurrence of calcium oxalate stone.