Clinical Observation On Sequential Therapy Of Yishen Tiaogan Method For Decreasing Ovarian Reserve Function

Objective: To observe the clinical efficacy of Decoshed Ovarian Reserve(DOR)in the treatment of spleen and liver function by using clinical controlled observational studies,and to explore whether Sequential Therapy of Traditional Chinese Medicine Yishen Tiaogan Method promotes menstrual physiological health It has the effect of improving the decline of ovarian reserve function.Method: Because the patient visits the hospital is different 60 patients with kidney-deficiency and liver-stagnation-type DOR who met the diagnostic criteria were divided into observation group and control group according to the patient's wishes,she becomes an experimental group or a control group.,and 36 cases were observed group(after late oral tutor experience,Fang Yichong was treated with Tang,and before the oral administration of Xuefu 24 cases were added to the control group,24 cases were the control group(Kingmeng/Fentongtong).After 3 months of continuous treatment,observe and record the menstrual status and TCM syndromes before and after treatment in the two groups of patients.The 2-3 days of menstruation were recorded.The measured basic hormones(bLH,bFSH,bE2 values),the number of antral follicles measured by B-ultrasound on the 5th-7th day of menstruation,and the size of the ovary;whether the natural pregnancy during the treatment period of the pregnant woman during the treatment period and within 3 months after the drug withdrawal There are no adverse reactions during and after treatment.The scores and medical statistics were observed before and after treatment.The data of ovarian function of DOR were observed by data analysis and statistical analysis.Results:(1)Clinical total efficacyThe observation group was 80.56% and the control group was 83.33%.The total clinical efficacy of the two groups was not statistically significant(P=1>0.05).(2)PregnancyThe pregnancy rate of the observation group was 11.11%,and the pregnancy rate of the control group was 12.5%.The pregnancy rate after treatment was not statistically significant(P=0.735>0.05).(3)Menstruation and TCM syndromesCompared with before treatment,the menstrual period,menstrual volume,menstrual cycle,menstrual cycle and meridian scores of the observation group were0.120,0.000,0.044,0.000,0.000,respectively,the difference was statistically significant(P<0.05);The cycle score was P=0.000,and the difference was statistically significant(P<0.01).The menstrual menstrual period,menstrual volume,menstrual color and meridian scores of the control group were 0.083,0.162,0.083,and 0.162,respectively.The difference was not statistically significant(P>0.05).Compared with the control group,the menstrual color,menstrual volume and meridian scores were0.000,0.013,and 0.022,respectively.The difference was statistically significant(P<0.05).The observation group was better than the control group.In the group,the observation group had backache,breast tenderness and abdominal pain P=0.000.The difference was statistically significant(P<0.01).The tinnitus and libido P were 0.160 and 0.083,respectively.The difference was not statistically significant(P> 0.05);control group,backache,breast pain,abdominal pain,loss of libido were 0.012,0.032,0.032,0.043,respectively,the difference was statistically significant(P <0.05),the control group tinnitus in terms of P = 0.083,the difference was not statistical Significance(P>0.05).Comparison between groups:observation group treatment of abdominal pain,breast tenderness,backache,P value were 0.038,0.045,0.012,the difference was statistically significant(P <0.05),in the tinnitus,loss of libido,P value was 0.496,At 0.906,the difference was notstatistically significant(P>0.05).(4)Related indicatorsCompared with before treatment,bFSH,bLH,bFSH/bLH were decreased in the two groups after treatment.The observation group P was 0.002,0.027,0.001,and the control group P was 0.000,0.002,and 0.011,respectively.The difference was statistically significant.(P<0.05);The contrast of E2 before and after treatment was0.852 and 0.704 in the observation group and the control group,respectively,and the difference was not statistically significant(P>0.05).The comparison between groups,bFSH,bLH,bFSH/bLH,bE2 values,P were 0.461,0.066,0.322,and 0.839,respectively,and the difference was not statistically significant(P>0.05).Before and after treatment,the number of antral follicles(AFC)and ovarian volume(OV)were compared.After treatment,AFC increased in both groups,P =0.000,the difference was statistically significant(P<0.01);OV contrast before and after treatment There were no significant changes in the control group and the control group,P were 0.111 and 0.057,respectively,and the difference was not statistically significant(P>0.05).After treatment with AFC and OV,P was 0.829 and 0.139,respectively,and the difference was not statistically significant(P>0.05).Conclusion:1.Yishen Tiaogan method for the treatment of kidney deficiency and liver stagnation type DOR has clear clinical effect,can improve bFSH,bLH level and bFSH/bLH value,increase AFC,the effect is close to Cengmeng/Fentongtong;can be improved The pregnancy rate is similar to that of fen.2.Yishen Tiaogan method sequential treatment of kidney deficiency and liver stagnation type DOR in the improvement of TCM syndrome(backache,breast pain,abdominal pain),menstruation(color,volume,menstrual meridian)Significant efficacy in these areas,better than gram Age Meng / Fen Tong Tong.Sequential treatment of DOR with Yishen Tiaogan method has no obvious effect on improving OV and E2 values.