Related Prognosis Factors Analysis Of Neoadjuvant Chemotherapy Combined With Modified Radical Mastectomy With Nipple-Areola Complex Spared For Breast Cancer

Objective To study the relationship between the clinicopathological data and the prognosis of neoadjuvant chemotherapy combined with modified radical mastectomy with nipple-areola complex spared for breast cancer,and to comprehensively analyze the related factors affecting the prognosis,so as to provide a scientific and effective basis for clinical application.Methods Patients who received neoadjuvant chemotherapy combined with modified radical mastectomy with nipple-areola complex spared for breast cancer in the department of breast and thyroid surgery of Tongde hospital of Zhejiang province or the department of breast tumor surgery of Zhejiang cancer hospital were selected as the research objects.Primary tumor size,axillary lymph node status,tumor-to-nipple distance,histological type,immunohistochemistry and other clinicopathological data were collected and recorded.Patients were followed up for recurrence,metastasis and survival after treatment.The main factors affecting the prognosis of patients receiving the combined therapy were analyzed by statistical methods.Results Sixty-eight of the subjects were women,and patients 50 and younger accounted for 76.4 percent,more than three-quarters of the total.There were 19 cases of recurrence or metastasis(27.9%),11 cases of local recurrence(including 7 cases of recurrence in the central region of the affected breast),and 8 cases of distant metastasis.A total of 5 patients died(7.4%),of which 1 patient died from other unrelated causes.Univariate and multivariate analyses showed that the longest diameter of the tumor,axillary lymph node status,tumor-to-nipple distance,the histological type of the tumor,and the expression of Her-2 in the tumor tissue were independent risk factors for postoperative disease-free survival.The recurrence rate of the central region of the affected breast was significantly different among the subjects whose tumor-to-nipple distance was less than 2.0cm and those whose tumor-to-nipple distance was greater than or equal to 2.0cm.There was no significant difference in the recurrence rate in the central region of the affected breast between invasive ductal carcinoma and other pathological types.Axillary lymph node status before treatment also affected overall survival.Conclusion The patients receiving neoadjuvant chemotherapy combined with modified radical mastectomy with nipple-areola complex spared for breast cancer were mostly women under 50 years old.Longest diameter of the tumor,axillary lymph node status,tumor-to-nipple distance,the histological type of the tumor,and the expression of Her-2 in the tumor tissue are independent risk factors for postoperative disease-free survival.When the tumor-to-nipple distance is greater than or equal to 2.0cm,the risk of oncology was lower.And infiltrating ductal carcinoma patients can accept the combined therapy.In addition,axillary lymph node status will affect overall survival meanwhile.