| OBJECTIVE: To investigate the risk factors of peripheral arterial disease in patients with type 2 diabetes,and to provide a scientific basis for reducing the incidence of peripheral arterial disease in patients with type 2 diabetes,preventing poor prognosis in patients with T2 DM,and improving the quality of life of patients.METHODS: This study based on the 2011 multi-center collaborative study on the epidemiological study of the risk of tumorigenicity in patients with type 2 diabetes in China,this study conducted an epidemiological field survey of 10,300 community residents in Dalian in 2011,obtained baseline data and established follow-up.In the cohort,441 patients(excluding patients with peripheral arterial disease)diagnosed with T2 DM were excluded from the inclusion criteria as the target population for this study.The study used a nested case-control study with a 1:3 ratio.The case group was T2 DM patients with newly diagnosed peripheral arterial disease at the time of 2014 follow-up,a total of 64 patients were matched according to the same gender and age difference of 3years old.The control group was T2 DM with no peripheral arterial disease in the follow-up cohort.For the patients,a total of 192 people were selected in the control group according to the 1:3 ratio.Data were managed and statistically analyzed using SPSS 21.0 software,and statistical analysis of data using conditional logistic regression analysis.Results: 1.Basic information of the study subjects: 64 cases were included in the case group,the average age was(65.72±6.835),including 15 males(23.4%)and 49 females(76.6%).The control group included 192 patients.The age was(65.65±6.69),45 males(23.4%)and 147 females(76.6%).2.Univariate analysis of risk factors for peripheral arterial disease in T2 DM patients showed: 1 clinical signs: duration of diabetes,fasting blood glucose and total cholesterol(TC),the difference between the case group and the control group was statistically significant(P<0.05)There were no significant differences in systolic blood pressure,diastolic blood pressure,postprandial 2 h blood glucose,TG,LDL-C and HDL-C between the case group and the control group(P>0.05).2 Body type factors:BMI factors in the case group and There was significant difference between the control group(P<0.05).There was no significant difference in WHR abnormality between the case group and the control group(P>0.05).3 Lifestyle habits: Smoking factor between case group and control group The difference was statistically significant(P<0.05);there was no significant difference in drinking,physical exercise and salt-free diet between the case group and the control group(P>0.05);4 different disease history:hyperuricemia,fatty liver There was a statistically significant difference in the history of fatty liver disease between the case group and the control group(P<0.05).There was no significant difference in the history of hypertension,congestive heart failure and stroke between the case group and the control group(P >0.05).3.Multivariate analysis of risk factors for peripheral arterial disease in patients with T2 DM showed that there were multiple factors that were risk factors for T2 DM patients with peripheral arterial disease.The OR(95% CI)were: 7.500(1.699 to 33.116)smoking,fatty liver.2.327(1.031 to 5.251),hyperuricemia 4.774(1.385 to 16.451),BMI 1.125(1.002 to 1.262),and fasting blood glucose 1.176(1.053 to 1.314).The course of hyperlipidemia,total cholesterol(TC)and diabetes was not statistically significant in multivariate analysis(P>0.05).Conclusion: 1.The higher the fasting blood glucose and BMI levels,the higher the risk of developing peripheral arterial disease in T2 DM patients.2.Smoking and fatty liver and hyperuricemia are risk factors for peripheral arterial disease in T2 DM patients. |
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