Research The Association Between Peripheral Arterial Disease And Risk Factors In Type2-diabetes Mellitus By Ultrasonography

Objective: Use2D-US to examine peripheral arterial of the patients withtype-2diabetes mellitus, observe the association between the risk factors andpathological degree.Method:(1) Choose60healthy people between26and50years old, use2D-US to measure intima-media thickness and lumen diameter of the anteriortibial artery, posterior tibial artery, dorsalis pedis artery, so as to set upphysiological ranges about the intima-media and lumen diameter.(2) Choose107diabetic inpatients in our hospital, measure the intima-media thickness andlumen diameter of their anterior tibial artery, posterior tibial artery, dorsalispedis artery, and observe whether there is spot, plaque in intima, whether there isstenosis or obliteration in the artery. Peripheral arterial disease can be dividedinto5models by the lesion degree. Research the association between thepathological changes and the risk factors: course of disease, hypertension,peripheral neuropathy, postprandial2h blood glucose, hemoglobin Alc, triglyceride, total cholesterol, high density lipoprotein-cholesterol, non-highdensity lipoprotein-cholesterol and lipoprotein a.Results:(1)The normal ultrasonogram of the peripheral arterial wall: Intimais a smooth hyperechoic ribbon, media is hypoecho and thicker, adventitia is ahyperechoic ribbon. Healthy peoples’ ultrasound physiological measurementsrange of the intima-media and lumen diameter were built.(2)Study groups weredivided into5models by the degree of the peripheral arterial disease.(3) Thereis positive correlation between the degree of the peripheral arterial disease andthe clinical index, laboratory index: postprandial2h blood glucose, totalcholesterol, non-high density lipoprotein-cholesterol, course of disease,peripheral neuropathy and hypertension, and the correlation indexes are:0.417,0.375,0.386,0.729,0.382,0.417, P＜0.05. There is no significant differencebetween the degree of the peripheral arterial disease and hemoglobin Alc,triglyceride, high density lipoprotein-cholesterol, and lipoprotein a, thecorrelation indexes are:0.142,0.008,0.090,0.142, P＞0.05. There is significantdifference for the degree of the peripheral arterial disease of the patients type2-diabetes mellitus between the group with peripheral neuropathy, hypertensionand the group without peripheral neuropathy, hypertension, P＜0.05.(4) Thereis positive correlation between the degree of the peripheral arterial disease andthe course of disease≤5yrs,＞5yrs, and the correlation indexes are:0.342,0.434, P＜0.05. There is significant difference for the degree of the peripheralarterial disease of the patients type2-diabetes mellitus between the group≤5yrsand＞5yrs, P＜0.05.Conclusion:2D-US could clearly show the nomal structures of theperipheral arterial wall: Intima is a smooth hyperechoic ribbon, media ishypoecho and thicker, adventitia is a hyperechoic ribbon. Ultrasound could measure the thickness of intima-media and lumen diameter.2D-US and CDFIcould assess the degree of the peripheral arterial disease. There is positivecorrelation between the degree of the peripheral arterial disease and followingindexes: postprandial2h blood glucose, total cholesterol, non-high densitylipoprotein-cholesterol, course of disease, peripheral neuropathy andhypertension. There is significant difference in the degrees of the peripheralarterial disease between the group≤5yrs, with peripheral neuropathy,hypertension and the group＞5yrs, without peripheral neuropathy，hypertension,P＜0.05.