Correlation Between MUL1 Gene Polymorphism And Parkinson's Disease

Objective: Parkinson's disease(PD)are torturing millions of patients worldwide and gene therapy may be a hope for cure.Recent researches indicated that MUL1 may play a role in PD pathogenesis,but no specific genetic variants has been identified.The present study was aimed to test the hypothesis that variants in MUL1 genes were associated with PD risk in a Chinese cohort from Xinjiang,China.Method: Ten SNPs of the MUL1 gene were genotyped using the direct DNA sequencing in a case-control study containing 100 PD patients and 100 controls matched for age and gender.Result: Our results revealed rs529974 in MUL1 gene was significantly associated with the risk of PD incidence.The allele T in rs529974(+)could cause additional PD tendency(OR= 0.353,95%CI:[0.179~0.712],P = 0.003)which was independent of gender,clinical features and PD symptom severity.Conclusion: The allele T in rs529974 in MUL1 gene was related with Parkinson's disease risk.MUL1 may become a biomarker for predicting the risk and early diagnosis of Parkinson's disease,but it still needs to be confirmed by larger studies.