Analysis Of Etiology And Clinical Characteristics Of Infection-related Infant Asthmatic Diseases

Objective:To observe the pathogenic distribution characteristics of infantile wheezing associated with infection,and analyze the effects of allergic factors on the clinical characteristics,the percentage of eosinophils and the abnormal rate of FENO of infectious wheezing,and explore the relationship between pathogen infection,allergies and wheezing in infants and young children,in order to identify early infants and young children who may have recurrent wheezing or asthma exacerbation,and provide early evidence for the diagnosis and treatment of infection-related infants asthmatic diseasesMethods:A retrospective analysis method was used to select 423 children who were hospitalized in the respiratory ward of DaLian Children's Hospital from February 2017 to February 2018.The children diagnosed with infection-related infants wheezing who were divided into infants and toddles according to age.The characteristics of the disease types and pathogens of the two groups were analyzed.According to the group of individuals with allergies,comparing the wheezing days,hospital stay,total disease duration,pathogen positive rate,eosinophil ratio and FENO abnormal rate between the two groups.Observing whether there are differences on the above indicators between the two groupsResults:1.Among the 423 children who met the inclusion criteria,296 were male and 127 were female,the ratio of male to female was 2.33.The average age was 0.96±0.74 years.There were 275 infants,202 were males,73 were females,there were 148 toddlers,94 were males and 54 were females.There were 208 allergic children,154 were males and 54 were females,with an average age of 0.97±0.74 years,there were 215 cases without allergies,142 were males and 73 were females,with an average age of 0.96±0.73 years.The incidence rate was the highest in winter,accounting for 51.3%,followed by spring incidence rate,accounting for 26.2%,summer incidence rate of 12.3%,and autumn incidence rate of 10.2%2.Among the 423 children who met the inclusion criteria,251 cases with acute bronchiolitis,accounting for 59.3%,111 cases with pneumonia with pneumonia and wheezing,accounting for 26.2%,31 patients with acute asthmatic bronchitis,accounting for 7.3%,and 30 cases of asthma with respiratory infection,accounting for 7.1%.In different age groups,the distribution of the disease-related infants with wheezing was different.In the infant group,the disease is mainly caused by acute bronchiolitis,following by pneumonia with wheezing;in the toddle group,pneumonia was associated with wheezing,followed by acute bronchiolitis3.Among the 423 children who met the inclusion criteria,392 had improved pathogenicity.The positive rate of pathogen was 42.6%,of which Mp.pneumoniae(MP)infection was the most common,with a positive rate of 21.2%.Respiratory syncytial virus(RSV)was second,with a positive rate of 17.3%.The infant group was mainly infected with RSV,and the toddle group was mainly infected with MP4.The average number of days of wheezing and hospital stay in the allergic group were higher than those in the non-allergic group.T-test showed that the difference was significant(P<0.05)5.The incidence of wheezing caused by RSV infection in allergic group was higher than that in non-allergic group.After ?2 test,the difference was significant(P<0.05)6.The mean percentage of eosinophils in the allergic group was higher than that in the non-allergic group.Compared with the two groups,the difference was statistically significant(P<0.05)7.The abnormal rate of FENO in children with allergic group was significantly higher than that in non-allergic group,which was compared with the matched four lattice?2 test,the difference was statistically significantConclusion:1.The incidence of infection-related asthmatic diseases were high in winter and spring,and acute bronchiolitis was the most common2.The detection rates of RSV and MP infection were the highest for the pathogens of infection-related infant asthmatic diseases.The infants group was mainly infected with RSV,and the toddlers group was mainly infected with MP,which provided theoretical basis for the treatment of antiviral and macrolide drugs in infants with acute stage of the disease3.Infants with a history of allergy are more likely to suffer from wheezing after RSV infection,its abnormal rate of FENO is higher,which suggesting a higher airway eosinophilic inflammation.The interaction between virus infection and allergy constitution increases the risk of repeated wheezing in infants,providing theoretical basis for early intervention in infants with infection-related wheezing.