The Relationship Of Fractional Exhaled Nitric Oxide And Peripheral Blood Eosinophils

Objective Discuss the percentage of exhalation nitric oxide and peripheral eosine cells in patients with acute onset of chronic obstructive pulmonary disease.The relationship between exhalation nitric oxide(FeNO)and its peripheral blood eosinophil percentage(EOS%)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)was investigated.Methods A total of 82 patients with AECOPD from October 2018 to June 2019 in Lu'an people's Hospital were divided into EOS > 2% group(positive group)and EOS? 2% group(negative group)according to the percentage of eosinophils in peripheral blood(EOS%).The general data,exhaled nitric oxide,hospitalization days of peripheral blood EOS%,and days of intravenous glucocorticoid use were measured and analyzed.Results Positive group of exhaled nitric oxide,peripheral blood EOS %,hospitalization days,glucocorticoid levels were significantly higher than the negative group(P < 0.05),and there was a positive correlation between the exhaled nitric oxide and the hospitalization days of peripheral blood EOS%,and the number of intravenous glucocorticoids used in the positive group(r = 0.401,0.356,0.304,P <0.05).There was a positive correlation between EOS% in peripheral blood and the number of days in hospital and the number of intravenous glucocorticoids used in the positive group(r = 0.362,0.376,P < 0.05).There was no significant difference in the correlation with peripheral blood,hospitalization days and the number of intravenous glucocorticoids used in negative group.Conclusion The percentage of eosinophils in peripheral blood of AECOPD patients is positively correlated with FeNO..Both of them complement each other in reflecting airway inflammation in AECOPD patients.They have important application value in guiding the treatment of glucocorticoids in patients with AECOPD and prognosis.