The Research Of The Association Between Homocysteine And Osteoporosis In Middle-aged And Elderly Patients With Type 2 Diabetes Patients

Objective:In recent years,plasma homocysteine(Hcy)appears as an independent risk factor in the pathological conditions of a variety of metabolic diseases,and osteoporosis(OP)is a common complication of middle-aged and elderly patients with T2 DM,prone to fractures and even disability.To death,this article explores the relationship between OP risk and plasma Hcy in middle-aged and elderly patients with T2 DM.Screening may affect the risk factors of bone mineral density(BMD)and provide new ideas for early prevention and treatment of osteoporosis in T2 DM patients.Methods:A retrospective analysis of the clinical data of 173 patients(70 males and 103females)who were diagnosed with type 2 diabetes over 50 years old from May 2018 to January 2019 in the Department of Endocrinology,the second hospital of dalian medical university,Hcy,bone mineral density,body mass index,glycated hemoglobin,blood calcium,blood phosphorus,parathyroid hormone,calcium reduction,high-sensitivity C-reactive protein,alkaline phosphatase,cholesterol,triglyceride,high-density lipoprotein,low-density lipoprotein,vitamin D,vitamin B12 were measured for each subject.According to the bone mineral density T value For each of the 3 groups(osteoporosis group,bone mass reduction group,normal bone mass group),one-way ANOVA,pearson correlation analysis and multiple linear regression The correlation between Hcy and osteoporosis and the risk factors for screening for bone mineral density were analyzed and defined as statistically significant at P < 0.05.Results:1.Comparisons of all observational indices among groups: the Hcy value of osteoporosis group was higher than that of normal bone mass group(P < 0.05),the age of osteoporosis group was older than that of osteopenia group and normal bone mass group(P < 0.05),and the BMI value of osteoporosis group was lower than that of normal bone mass group(P < 0.05),glycosylated hemoglobin,serum calcium,blood phosphorus,parathyroid hormone,calcitonin,high-sensitivity C-reactive protein,alkaline phosphatase,cholesterol,triglyceride,high-density lipoprotein,low density There was no significant difference in lipoprotein,vitamin D and vitamin B12(P>0.05);2.Pearson correlation analysis: Hcy(r=-0.23,P=0.003)and age(r=-0.36,P=0.000)were negatively correlated with bone mineral density,BMI(r=0.26,P=0.001)was positive correlation with bone mineral density,no other indicators were associated with bone mineral density(P>0.05);3.Multiple linear regression analysis: With bone density as the dependent variable(Y),all observed indicators were independent variables(X),and the regression equation was obtained: Y=0.077×BMI-0.047×Hcy-0.041×年龄-0.632.Note: 2 and 3 prove that Hcy is negatively correlated with BMD,BMI is positively correlated with BMD,but because BMD is negatively correlated with the risk of osteoporosis,Hcy and age are positively correlated with the risk of osteoporosis,BMI is negatively correlated with the risk of osteoporosis.Conclusions:1.Among the patients with osteoporosis in T2 DM,Hcy,age and BMI are the risk factors of osteoporosis.Hcy and age are positively correlated with the risk of osteoporosis,while BMI is negatively correlated with the risk of osteoporosis.The older the Hcy and the older the age,the greater the risk of osteoporosis,the greater the BMI,the smaller the risk of osteoporosis.2.Glycated hemoglobin,blood calcium,blood phosphorus,parathyroid hormone,calcitonin,high-sensitivity C-reactive protein,alkaline phosphatase,cholesterol,triglyceride,high-density lipoprotein,low-density lipoprotein,vitamin D,There was no significant correlation between vitamin B12 and bone mineral density.