Analysis Of The Correlation Between ADC Value Of Diffusion Weighted Imaging And Ki-67 Expression In Non-Hodgkin Lymphoma Of Head And Neck

Objective:To investigate the correlation between apparent diffusion coefficient(ADC)and prognostic factor Ki-67 expression in non-Hodgkin's lymphoma(NHL)of head and neck and the effect of ADC value in evaluating the efficacy of NHL chemotherapy.Methods: A total of 42 patients underwent MRI examination at the Affiliated Tumor Hospital of Xinjiang Medical University and confirmed by pathology as NHL of head and neck from September 2017 to July 2018.Excluding other pathological types,they were divided into NK-T cell lymphoma(NKTCL)group and diffuse large B cell lymphoma(DLBCL)group.According to Ki-67 index,the patients were divided into two groups: low expression group(Ki-67<50%)and high expression group(Ki-67>50%).According to the change of tumor size before and after chemotherapy,the patients were divided into two groups: the changes group and the no changes group.The ADC value of each group was calculated and the correlation between the ADC value and the expression of Ki-67 was analyzed.Results:The average ADC value was negatively correlated with the Ki-67 index(r=-0.779,P=0.000).The average ADC value of low expression group was significantly higher than that of high expression group(P=0.000).The ADC values of Ki-67 low expression group and high expression group were negatively correlated with Ki-67 index(P < 0.05).The ADC values of DLBCL group and NKTCL group were negatively correlated with Ki-67 index(P < 0.05).There was no significant difference in ADC and Ki-67 between NKTCL group and DLBCL group(P>0.05).The difference of the ADC value in the changes group was significantly different(P < 0.05).The difference of ?ADC of the changes group was significant different with the no changes group(P<0.05).Conclusion:The ADC value is related to the expression of Ki-67 in NHL of head and neck.The lower the ADC value,the higher the Ki-67 index in NHL.The changes of ADC value can monitor the effect of chemotherapy.Accordingly,DWI combined with MR routine scan can non-invasively evaluate the biological behavior in NHL of head and neck.