Behavioral And Electropsysiological Study In Depression Patients With Anhedonia

Objective: Depression is a common mental illness and a mood disorder.Mainly manifested as low mood,lack of interest,fatigue and other symptoms,severe depression patients will have suicidal behavior.Ahnedonia is one of the core symptoms of depression,and has a relationship with reward.However,the clinical evaluation of the lack of pleasure in depression is lacking.Therefore,this study explored the anhedonia scale and documented the behavioral and neurophysiological indicators of patients with depression in the reward responsing bias paradigm.The aim is to study the lack of pleasure in depression from different ways and to explore the neural mechanism of depression in the depression.In turn,it can better assess the degree of pleasure in patients with depression and provide a standard for further clinical intervention.Methods:?The Chinese version of DARS was used to assess 318 undergraduate students,83 of whom participated in the retest four weeks later.?Research on health control group(33)and depression patients group(46)using the reward response bias paradigm;According to Dimensional Anhedonia Rating Scale,the depression group were divided into high anhedonia group(21)and low anhedonia(21),and research on two group using the reward response bias;According to Temporal Experience Pleasure Scale-sub scale,anticipation anhedonia scale,the depression group were divided into high anticipation anhedonia group(18)and low anticipation anhedonia group(16),and research on two group using the reward response bias.?Applying the reward response bias paradigm to event-related potentials,research on health control and depression group.Results:Result one:Cronbach's ? coefficients of the Chinese version of DARS was0.909,test-retest reliability of the Chinese version of DARS was 0.959,The total score of DARS and four sub-scales were positively associated with that of BDI?SDS?SHAPS?TEPS and its sub-scales in the total sample.Indicates that the DARS scale has good reliability and validity.Result two:(1)There is a significant difference between the health control group and the depression group in discriminability with Block1 and Block2(P<0.05).The discrimination of patients in the depression group was significantly lower than that in the normal group.There is a no significant difference between the health control group and the depression group in Block3;There is a significant difference between the health control and the depression group in responsing bias with Block2 and Block3(P<0.05).The discrimination of patients in the depression group was significantly lower than that in the normal group.There is a no significant difference between the normal group and the depression group in Block1(P>0.05);There is a no significant difference between the normal group and the depression group in reation time(P>0.05).(2)There is a significant difference between the high anhedonia group and the low anhedonia group in Block2&Block3(P<0.05),There is a no significant difference between the high anhedonia group and the low anhedonia group in Block1(P>0.05);There is a no significant difference between the high anhedonia group and the low anhedonia group in discrimility ang rection time;There was a significant positive correlation between the DARS scale score of the high anhedonia group and the resposing bias of Block1(r=0.515,P<0.01)Block2&3(r=0.719,P<0.01).(3)There is a significant difference between the high anticipation anhedonia group and the low anticipation anhedonia group in responsing bias of Block3(P<0.05).There is a no significant difference between the high anticipation anhedonia group and the low anticipation anhedonia group in responsing bias of Block1?Block2(P<0.05);Thereis a no significant difference between the high anticipation anhedonia group and the low anticipation anhedonia group in reaction time and discrimility;There was a significant positive correlation between the score of TEPS sub-scale and the reasponse bias of Block2(r=0.593,P=0.01<0.05).Result three:The FN amplitude of the depression group was significantly lower than that of the normal group(P<0.05).The total score of the DARS scale in the depression group was significantly positively correlated with the mean amplitude of Gain-FN(r=0.821,P<0.01);BDI There was a significant negative correlation between the total score of the scale and the average amplitude of Gain-FN(r=-0.422,P<0.05).Conclusion:Conclusion one:The Chinese version of the Dimensional Anhedonia Rating scale has good reliability and validity.Conclusion two:The depression group was unable to recognize the reward stimulation level compared with the normal control group;the high pleasure group and the low pleasure group in the depression group,the high expectation type of pleasure group and the low expectation type group were in the upward bias of the reward.Conclusion three:People with depression are not sensitive to rewards.The higher the degree of pleasure loss,the smaller the FN amplitude,that is,the symptom of the lack of pleasure in depression affects the patient's response to the reward and does not produce a pleasant experience for the reward.