Effect Of Carboprost Suppositories At Different Time On The Amount Of Postpartum Hemorrhage Of Scar Uterus

Objective To evaluate the effectiveness and safety of bleeding Carprost Suppositories administered at different time to reduce the scar uterus of two cesarean section during and after the operation,in order to improve the understanding of Carprost in clinical obstetrics applied correctly,as far as possible to reduce bleeding,reduce the blood transfusion rate,hysterectomy rate and mortality of maternity.Methods The clinical study of 120 pregnant women in Bengbu Third People's Hospital from January 2017 to December 2017 for the termination of pregnancy due to scar uteri was selected.All the subjects were randomly divided into four groups:The matched group(simple oxytocin group 40 cases): fetus after intrauterine injection of oxytocin 20 U + 20 U oxytocin intravenous drip;the experimental group one(Carprost group one 40 cases): 2 minutes before the delivery of the fetus give the carboprost 1mg sublingual + fetus after shrinkage 20 U intrauterine injection of oxytocin and oxytocin intravenous infusion of 20U;the experimental group two(Carprost group 40 cases: two)after delivery of fetus were given carboprost 1mg sublingual + oxytocin 20 U intrauterine injection plus Oxytocin intravenous infusion of 20 U.The amount of bleeding during operation,postoperative 2 hours bleeding,postoperative 24 hours total bleeding volume,incidence of postpartum hemorrhage and incidence of adverse reactions of control group were collected.Results 1.The amount of blood loss during operation in 3 groups respectively: control group(412.30±34.58ml),experimental group one(235.43±40.50ml),experimental group two(252.48±37.60ml),the control group and the experimental group two and experimental group,there were statistically significant differences(P<0.05),the first experimental group compared with the experimental group two,the difference between statistically significant(P<0.05).2.The amount of bleeding in 2 hours were respectively 3 groups : control group(203.40±23.60ml),group one(115.25±28.50ml),group two(135.53±30.52ml),three groups,there were statistically significant differences(P<0.05,),the first group compared with the group two,the difference exists(P<0.05).3.The amount of bleeding in 24 hours were respectively 3 groups after operation: control group(358.76±25.40ml),experimental group one(298.52±22.70ml),experimental group two(312.47±30.42ml),the control group and the experimental group two and experimental group,there were statistically significant differences(P<0.05,),the first experimental group compared with the group two,the difference the statistical significance(P<0.05).4.The incidence of postpartum hemorrhage: control group(12.5%),experimental group one(2.5%),experimental group two(5%),and experimental group one and group two comparison,there were statistically significant differences(P<0.05),the first experimental group compared with the experimental group two,the difference was statistically significant(P<0.05).5.The incidence rate of adverse reaction: control group(15%),experimental group(17.5%),control group and experimental group one and two experimental group,there were statistically significant differences(P<0.05).Conclusion 1.Carboprost in reducing bleeding and postoperative scar uterus of two caesarean section has good clinical effect on the fetus,before 2min sublingual better.2.The clinical application of the Carboprost is high in safety.The main side effects are nausea,vomiting and diarrhea.The duration is short,and it can be improved without special treatment.