Correlation Of Visceral Fat Area With Carotid Intima-media Thickness And Lifestyle

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The relationship between visceral fat area and carotid intima-media thickness in patients with type 2 diabetes mellitus.ObjectiveTo investigate the correlation between visceral fat area and carotid intima-media thickness in patients with type 2 diabetes.MethodsThis was a cross-sectional study.A total of 542 male and female patients with type 2 diabetes hospitalized in Department of Endocrinology of Shandong Provincial Hospital from January 2016 to October 2018 were randomly selected.Clinical data,including demographic data and medical history,were collected from all subjects.Height,weight,and blood pressure were measured.Fasting plasma glucose(FPG),fasting insulin(FINS),glycosylated hemoglobin(HbAlc),alanine aminotransferase(ALT),aspartate aminotransferase(AST),creatinine(Scr),glomerular filtration rate(eGFR),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),retinol-binding protein(RBP),uric acid(UR),C-reactive protein(CRP),white blood cells(WBC),neutrophils(NEUT),monocytes(MONO)and other biochemical parameters were measured in the morning cubital vein after a 12-hour fast.Body mass index(BMI)and insulin resistance index(HOMA-IR)were calculated.Visceral fat area(VFA)was measured by InBody720 body composition analyzer.Carotid artery intima-media thickness(CIMT)was measured by color Doppler ultrasound.Statistical analysis:SPSS 22.0 statistical software was used for data collation and analysis,and P<0.05 was considered statistically significant.Results1.Compared with the normal group,the duration of diabetes,age,weight,systolic blood pressure,smoking,FPG,LDL-C,HOMA-IR and CRP levels were significantly higher in the CIMT thickening group,and the differences were statistically significant(all P<0.05).2.Age,VFA,BMI,TG,UA,and CIMT were higher in the group with increased visceral fat than in the group without increased visceral fat,and the differences were statistically significant(P<0.05).CIMT was significantly higher in the simple visceral lipomatosis group than in the non-obese group(all P<0.05).3.Correlation analysis showed that CIMT was positively correlated with VFA,age,duration of diabetes,SBP,FPG,LDL-C,and CR(P<0.05),and negatively correlated with TG,AST,ALT,MONO,and NEUT(P<0.05);VFA was positively correlated with gender,weight,BMI,SBP,DBP,FPG,TQ CRP,RBP,and UR,and negatively correlated with HDL-C(P<0.05).4.Multiple linear regression with CIMT as the dependent variable and adjusted for gender,age,duration of diabetes,gender,smoking,SBP,FPG,LDL-C,MONO,NEUT and other influencing factors showed that VFA was still an independent factor for CIMT.ConclusionCompared with BMI,VFA was more closely related to CIMT,and visceral fat area had a more significant effect on CIMT in patients with type 2 diabetes.Part ? The study of visceral fat area and lifestyleObjectiveTo explore the relationship between visceral fat area and lifestyle,in order to guide the population diet,prevention and treatment of obesity.MethodsA random sampling method was used to select the population in our department in 2014 in Ningyang County,Tai'an City,Shandong Province as the study subjects to investigate the basic conditions,living behaviors,dietary types and other data of the subjects;measure the physical indicators such as height and weight of the subjects and calculate the body mass index;determine the biochemical indicators of cubital vein in the morning after 12 hours of fasting;investigate the food intake of the population using the diet frequency table;measure the VFA using the Inbody 720 body composition analyzer;statistical processing:use the SPSS 22.0 statistical software for data collation and analysis.Results1.A total of 797 subjects were included in this study,346 males and 451 females.Compared with men,women had lower DBP,HbAlc,CHOL,LDL-C,VFA,smoking prevalence,and drinking rate than men,and the differences were statistically significant(all P<0.05).2.There was a significant difference in VFA between groups for alcohol consumption,physical exercise,and sedentary time in men(p<0.05),and there was no significant difference between sedentary time and VFA in women(p>0.05).3.Regression analysis of non-dietary factors for VFA showed that:age(OR=1.183,95%CI:1.076-1.302),alcohol consumption(OR=2.036,95%CI:1.348-3.076),physical exercise(OR= 0.732,95%CI:0.650-0.824)sedentary time(OR=1.327,95%CI:1.101-1.599)were independent factors associated with VFA(P<0.05).4.After grouping the study subjects according to the quartile method of various food intakes(Q1 to Q4),one-way ANOVA revealed that there was a significant difference in VFA among different intake quartiles of livestock and poultry meat,animal viscera,vegetable oil,and fried food(P<0.05)5.Binary logistic regression analysis showed that livestock and poultry meat,vegetable oil,and fried food were risk factors for VFA;vegetables were protective factors for VFA(P<0.05).ConclusionUnreasonable dietary structure and poor lifestyle are the main reasons for the increase in visceral area.Patients with more visceral fat area should have a reasonable diet on weekdays to cultivate a healthy lifestyle and avoid visceral fat accumulation.