Effect Of Jianpi Yishen And Huoxue Xiezhuo Method On Microinflammation Status In Patients With CKD Stage 4 (Spleen And Kidney Deficiency,Turbidity And Internal Resistance)

Objective: To explore the clinical efficacy of Jianpi Yishen and Huoxe Xiezhuo in the treatment of microinflammation in patients with CKD stage 4(spleen and kidney qi deficiency and phlegm and internal obstruction).Methods: Sixty patients with CKD stage 4(spleen and kidney qi deficiency and phlegm internal resistance type)who met the inclusion criteria in our outpatient and inpatient wards were randomly divided into treatment group and control group.The control group was given conventional treatment.The treatment group was supplemented with Yishen Detoxification Decoction and Yishen Huoxue Recipe.Both of the two groups were treated continuously for3 months.Observe the changes of microinflammation indicators(hs-CRP,IL-6,TNF-?),renal function indexes(Scr,BUN,eGFR),Hb,ALB,blood lipids(TG,TC,LDL-C,HDL-C)and scores of TCM symptoms at the end of treatment.Then use the statistical methods to analyze the data and value the efficacy.Results:(1)Comparison of microinflammation indicators: After treatment,the levels of hs-CRP and IL-6 were decreased in both groups,and the results were statistically different(P<0.01 or P<0.05).The comparison between the two groups was statistically significant(P<0.01 or P<0.05).After treatment,the levels of TNF-? in the two groups were decreased.Change in the treatmentgroup was statistically significant(P<0.01).However,no significant change has been found in the control group(P>0.05).The comparison between the two groups was statistically significant(P<0.01).(2)Comparison of renal function indexes: After treatment,the levels of Scr and BUN in the treatment group were apparently different from the ones before treatment,and the results were statistically significant(P<0.05).There was no significant difference in the comparison between Scr and BUN values in the control group.(P>0.05);The comparison between the two groups was statistically significant(P < 0.01orP<0.05).The patients in the treatment group had elevated eGFR compared with the ones before treatment,and the results were statistically significant(P<0.05).There was no increase in eGFR in the control group,the results were not statistically significant(P>0.05);After treatment,the eGFR value's comparison between the two groups was statistically significant(P < 0.05).(3)Comparison of hemoglobin and albumin: After treatment,the levels of Hb and ALB in the two groups were increased,which was statistically significant compared with that before treatment(P<0.01 or P<0.05).There was no statistical comparison between the two groups significance(P>0.05),the comparison between the two groups of ALB levels was statistically significant(P<0.05).(4)Comparison of blood lipid indexes: After treatment,the levels of TC,TG and LDL-C in the two groups were lower,and the results were statistically significant(P<0.01 or P<0.05).Compared with the TC and TG levels,the two groups had Statistical difference(P<0.05),LDL-C value was not statistically significant(P>0.05).After treatment,the HDL-C level in the treatment group was significantly increased,the results were statistically significant(P<0.01);the HDL-C level in the control group did not increase significantly,the results were not statistically significant(P>0.05);Groups ofHDL-C levels were statistically different.(5)Comparison of TCM syndrome scores: After treatment,the TCM syndrome scores of both groups were decreased,and the results were statistically significant(P<0.05).Compared with the control group,the TCM syndrome scores of the treatment group were lower than those of the control group.Obviously,the difference was statistically significant(P < 0.05).(6)Comparison of TCM Syndrome Efficacy: After treatment,the TCM syndrome efficacy rate was 82.6% in the treatment group and 66.67% in the control group.The difference between the two groups was statistically significant(P<0.05).Conclusion:(1)Jianpi Yishen,Huoxue Xiezhuo method can effectively reduce the levels of serum hs-CRP,IL-6 and TNF-? in patients with CKD stage 4(spleen and kidney qi deficiency and phlegm obstruction)and improve microinflammation.(2)Jianpi Yishen,Huoxue Xiezhuo method can improve renal function,blood lipids,anemia and nutritional indicators in patients with CKD4(spleen and kidney qi deficiency,phlegm and internal resistance),reduce chronic kidney disease complications,and delay the progression of CKD.(3)Jianpi Yishen,Huoxue Xiezhuo method can effectively improve the clinical symptoms of patients with CKD4(spleen and kidney qi deficiency,phlegm and internal resistance)and improve the treatment efficiency.