Clinical Observation And Mechanism Of Naoxinkang On Patients With Vascular Dementia

Objective:To observe the clinical effect of naoxinkang on vascular dementia and discuss its mechanismMethods:Patients with vascular dementia admitted to our hospital from May 2017 to July 2018 were randomly divided into control group and study group,with 30 cases in each group.The control group was given basic treatment of western medicine:anti-platelet aggregation drugs,lipid-regulating drugs,acetylcholinesterase inhibitors,hypoglycemic drugs,antihypertensive drugs.The research group was given naoxinkang in addition to the basic treatment of western medicine.Both groups were evaluated for clinical efficacy after 3 months of administration.At 3 months and 6 months after treatment,MMSE score,ADL score,TCM syndrome differentiation scale score of vascular dementia,cerebrovascular blood flow velocity test and blood lipid level test were performedResults:The total clinical effective rate in the study group was significantly higher than that in the control group(73.33%vs.43.33%at 3 months;96.67%vs.90.00%at 6 months),the differences were statistically significant(P<0.05).There was no significant difference in MMSE score,ADL score and TCM syndrome differentiation scale score between the two groups before treatment(P>0.05).The MMSE and ADL scores at 3 and 6 months after treatment in both groups were significantly higher than those before treatment,and the scores of TCM syndrome differentiation scale were significantly lower than those before treatment(P<0.01).MMSE scores at 6 months after treatment in both groups and ADL scores at 6 months after treatment in the study group were significantly higher than those at 3 months after treatment,and both MMSE scores and ADL scores in the study group at 6 months after treatment were better than those in the control group(P<0.01,P<0.05).The score of TCM syndrome differentiation scale of the two groups at 6 months after treatment was significantly lower than that at 3 months after treatment,while the score of TCM syndrome differentiation scale of the research group at 6 months after treatment was significantly lower than that of the control group,and the difference was statistically significant(P<0.01).At 3 months after treatment and 6 months after treatment,the cerebral blood flow velocity of bilateral anterior cerebral artery,middle cerebral artery and posterior cerebral artery in the two groups was significantly higher than that before treatment,and the blood lipid was significantly decreased(P<0.01).Moreover,the blood flow velocity of all cerebral vessels in the two groups was significantly increased at 6 months after treatment compared with 3 months after treatment(P<0.05).Total lipid cholesterol(TC)in the study group and low density lipoprotein(ldl-c)in the two groups were significantly reduced after 6 months of treatment compared with 3 months of treatment(P<0.05).In the study group,the increase of cerebral vascular blood flow velocity was more obvious at 6 months after treatment than in the control group,and the decrease of TC and ldl-c levels was more obvious than in the control group,the difference was statistically significant(P<0.01).The blood flow velocity of right cerebrovascular and left MCA in the study group was significantly higher than that in the control group(P<0.05).TC in the study group decreased significantly compared with that in the control group at 3 months(P<0.05).Conclusion:Naoxinkang can improve the cognitive level,life ability and clinical symptoms of vascular dementia patients,and its mechanism may be through increasing the speed of cerebral blood flow and reducing the level of blood lipid.