Analysis Of Relative Factors Of Early Postoperative Epilepsy Of Cerebral Cortical Based Tumors

Objective: To discuss the correlation between various related factors and early epileptic seizures after operation of cerebral cortical based tumors(CCBT).Single factor analysis was performed by chi-square test and Kruskal-Wallis H rank sum test.And binary linear multivariate Logistic regression analysis was used to find out the risk factors and protective factors of early postoperative epileptic seizures in order to improve the safety of perioperative period reduce the occurrence of complications and improve the quality of life of patients.Methods: The clinical data of 167 patients with cortical and subcortical brain tumors who underwent craniotomy from October 2014 to October 2018 were collected.Epilepsy occurred within 7 days after operation as a dependent variable.The correlation analysis variables of early postoperative epilepsy were divided into counting data and metrological data.Sorting out the relevant data,using SPSS 22.0 statistical software for statistical analysis.First,univariate analysis was used for screening,Pearson-square test was used for the binary count data,and Kruskal-Wallis-H rank sum test was used for the data of age,operation time,tumor diameter and so on,which were re-grouped into disordered multi-classification variables.For independent variables with significant significance by univariate analysis,binary linear multi-factors Logistic regression analysis was performed.The level of test was p < 0.05,the difference was statistically significant.Results: There were 18 cases of early postoperative epilepsy,the incidence was10.78%.The results of univariate analysis showed that the history of pre-operative epilepsy,postoperative tumor-cavity bleeding,the degree of surgical resection,and the post-operative infection after operation,the postoperative pathological grade were related to the early-stage epileptic seizure after the brain tumor in the cortex and the cortex(p <0.05).The results of multivariate Logistic regression analysis showed that that the history of pre-operative epilepsy,postoperative tumor-cavity bleeding,degree of tumor resection,tumor hemorrhage,postoperative infection,postoperative pathological grade was associated with early postoperative seizures.The degree of tumor resection and postoperative pathological grade were protective factors(OR < 1)and others were risk factors(OR > 1).There was no significant difference in tumor recurrence,tumor location,operative approach,operative time and postoperative pathological type of AEDs,(P > 0.05).Conclusions:1.The results showed that the incidence of early epilepsy after operation was 10.78%in cortical or subcortical tumors;2.Pre-operative history of epilepsy,postoperative tumor-cavity bleeding,degree of tumor resection,tumor hemorrhage,postoperative infection with high fever,postoperative pathological grade were associated with the occurrence of early postoperative epilepsy;3.The degree of tumor resection and postoperative pathological grade were protective factors of early postoperative epilepsy,while other factors(pre-operative history of epilepsy,postoperative tumor-cavity bleeding,tumor hemorrhage and postoperative infection with high fever)were risk factors.4.Other factors such as age,gender,peritumoral edema,tumor recurrence,tumor location,surgical approach,operative time,postoperative pathological type,pneumocranium,water and electrolyte disturbance after operation were not significantly related to the occurrence of early postoperative epilepsy.5.These risk factors should be used in time to regulate the use of antiepileptic drugs for prevention or treatment.6.Prophylactic use of antiepileptic drugs before operation had no significant effect on the incidence of early postoperative epilepsy.