Analysis Of The Facters Of Recurrence After Discontinuation Of Antiepileptic Drugs In The First Year In Children With Idiopathic Epilepsy

Objective:To observe the Children With Idiopathic Epilepsy who were received AED therapy and seizure-free and withdrawal at least 1 year, and analysis the risk factors of seizure recurrence, in order to give better instruction for AED withdrawal of children with idiopathic epilepsy in pediatric of our hospital to a certain extent.Methods:Children with idiopathic epilepsy who were seizure-free and had stopped AED treatment at least 1 year before the deadline of observation were collected from pediatric outpatient and inpatient department of The First Affiliated Hospital of Guangxi Medical University from January 2011 to January 2014.The following variables, derived from the case records were analyzed:sex, age at seizure onset, type of seizure, time period between the onset of the first seizure and start of treatment, number of seizures in the time period between the start of AED therapy and the last seizure, number of AEDs before remission, time period between the start of AED therapy and the last seizure, time period between the last seizure and withdrawal of AED treatment (seizure-free period, timing of AED withdrawal), time period between the start of AED withdrawal and total discontinuation(speed of withdrawal), EEG registered at the time of diagnosis, before AED withdrawal, during and after AED withdrawal, and the condition of recurrence, using multivariate stepwise Cox regression model analysis.Results:A total of 16(12.8%)children relapsed in a total number of 125 children with idiopathic Epilepsy collected; Date evaluated by multivariable analysis showed that the children suffering from seizure type of focal seizure, starting withdrawal after a seizure-free period of less than 3 years and with abnormal post-withdrawal EEG recording was associated with a higher risk of seizure recurrence.Conclusions:Children with idiopathic epilepsy have a low risk of recurrence after AED withdrawal. Those who suffer from seizure type of focal seizure, start withdrawal after a seizure-free period of less than 3 years and with abnormal post-withdrawal EEG recording are associated with a higher risk of seizure recurrence.