Classification,syndrome Distribution Of 103 Cases Of Interstitial Pulmonary Diseases And Their Correlation With T-SPOT

Objective:The clinical data of 103 inpatients with interstitial lung disease?ILD?were retrospectively analyzed.The classification of ILD and the distribution of TCM syndromes were mastered.The correlation between ILD and T-SPOT was explored,which could provide some reference for the diagnosis,differential diagnosis and treatment of ILD.Methods: Through retrospective analysis of the general data,clinical diagnosis,syndrome differentiation,T-SPOT,blood gas,lung function and other clinical data of inpatients with ILD in respiratory department of Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University from January 2015 to December 2017,the difference of T-SPOT positive rate among different types of ILD and T-SPOT positive rate among different types of ILD were analyzed by means of₂ test.(FEV1 and PaO 2 were used to score pulmonary function damage and hypoxia degree,and t test was used to analyze the difference of pulmonary function damage and hypoxia degree score between T-SPOT positive group and T-SPOT negative group;Spearman rank correlation was used to test the correlation between T-SPOT positive value and pulmonary function damage and hypoxia degree score.Results:?1?There were 60 males and 43 females in 103 inpatients with ILD.Age distribution: 89-80 years old 22 people,79-70 years old 38 people,69-60 years old 24 people,59-50 years old 12 people,49-40 years old 7 people.?2?Of 103 inpatients with ILD,56?54.4%?were in the known cause group and 47?45.6%?were in the unknown cause group;47?45.6%?were in the known cause group,including17?16.5%?related to rheumatoid arthritis,12?11.7%?related to other connective tissue diseases,10?9.7%?related to Sjogren's syndrome,and 8?7.8%?related to vasculitis.There were 6 cases?5.8%?with chemical correlation and 3 cases?2.9%?with allergic alveolitis.?3?Among 103 inpatients with ILD,38?36.9%?suffered from Qi deficiency and blood stasis,20?19.4%?suffered from dryness,17?16.5%?suffered from phlegm-heat stagnation,14?13.6%?suffered from lung-qi deficiency,10?9.7%?suffered from phlegm turbidity,and 4?3.9%?suffered from phlegm-blood stasis stagnation.?4?Among 103 inpatients with ILD,24?42.9%?were T-SPOT positive in known cause group,23?48.9%?in unknown cause group,7?41.2%?were rheumatoid-related positive,5?62.5%?were vasculitis-related positive,4?40%?were Sjogren's syndrome-related positive,3?25%?were connective tissue disease-related positive,and 4?25%?were idiopathic pulmonary interstitial fibrosis-related positive.?66.7%?and 1?33.3%?were allergic alveolitis-related positive.19?50%?were positive for Qi deficiency and blood stasis,9?52.9%?were positive for T-SPOT,8?57.1%?were positive for lung-qi deficiency,6?30%?were positive for lung dryness,5?50%?were positive for phlegm-heat stagnation,and 0?0%?were positive for phlegm-blood stasis interaction.There was no significant difference in T-SPOT positive rate among different types of ILD?p > 0.05?,and there was no significant difference in T-SPOT positive rate among different types of ILD?p > 0.05?.?5?There were significant differences in lung function impairment and hypoxia scores between T-SPOT positive group and T-SPOT negative group?p < 0.01?.?6?There was no correlation between ILD pulmonary function impairment and hypoxia score and T-SPOT value in T-SPOT positive group?p > 0.05?.conclusion:?1?The majority of 103 patients in this study were elderly males,and nearly half of them were still unable to make a definite diagnosis,suggesting that the etiological diagnosis of ILD is still difficult.?2?Qi deficiency and blood stasis are the most common syndromes of ILD.?3?T-SPOT may not be related to the classification of ILD and the distribution of syndromes.?4?The severity of lung function damage and hypoxia in patients with ILD and T-SPOT positive may be more serious.It may be inferred that T-SPOT positive indicates an aggravating trend in the development of ILD.It may be inferred that T-SPOT positive can evaluate the severity and prognosis of ILD,and further observation and study should be carried out with expanded samples.