| BackgroundThe current mechanism for the formation of alcohol dependence has not been clarified,leading to the difficulty of alcohol dependence treatment.Cognitive dysfunction is one of the main symptoms of alcohol dependence,which is manifested in damages such as overall cognition,attention function,memory function and executive function.Numerous studies have shown that alcohol-dependent cognitive impairment may be the result of functional changes in the brain,but the current research results are different.Emerging functional brain imaging can explore changes in brain brain function.Resting state functional magnetic resonance imaging(rs-fMRI)can detect changes in brain function activity at rest and discover The damaged brain area at rest.Further explore the correlation between brain activity changes and cognitive impairmentObjectiveIn this study,a resting-state functional magnetic resonance scan was performed on alcohol-dependent patients and healthy drinking groups.By comparing the brain regions of the two groups with low-frequency amplitude(ALFF)values,the functional activities of brain regions in alcohol-dependent patients were found.At the same time,cognitive function tests were performed on the two groups to study the relationship between functional activity changes in brain regions and cognitive impairment in alcohol-dependent patients,which provided a new basis for clinical diagnosis and treatment of patients with alcohol dependence.MethodsTwenty-three alcohol-dependent hospitalized patients were selected as subjects,and they were required to stop drinking alcohol for at least 2 weeks and stop sedative drug replacement therapy.Twenty healthy adults were in the control group and required basic information(gender,age,years of schooling,etc.)to match the study group.First,the two groups of cognitive functions were tested: Simple Mental Status Scale(MMSE),Digital Breadth Test(DST),Connection Test B(TMT-B),Word Fluency Test(VFT),and Hopkins Word Learning.The revised version of the test(HVLT-R)was used to collect resting brain imaging data using Siemens 3.0 T MRI after the relevant assessment was completed.The differential brain regions of the two groups were calculated by statistical methods,and the characteristics of drinking and cognitive function were compared.The evaluation results were analyzed for correlation.Results1.The results of neuropsychological assessment in the alcohol-dependent group compared with the control group: MMSE score(t=-4.328),DST score(t=-4.932),VFT score(t=-2.859),and HVLT-R score(t=-5.165)Both were significantly lower than the control group(P<0.01);the TMT-B completion time(t=4.676)was significantly higher than the control group(P<0.01).The above differences are statistically significant.2.Compared with the control group,the alcohol-dependent group had lower ALFF values in the brain area: right upper temporal gyrus(39 3-18)(t=-5.362),left upper frontal back(-3 60 21)(t=-4.499),right frontal middle back(39 54 24)(t=-3.554),left side buckle back(0 21 36)(t=-5.418),brain area with elevated ALFF value: left side pillow Leaves(-36-63-15)(t = 3.901),posterior cerebellum(-27-57-54)(t = 3.581).The above differences were statistically significant(P<0.01).3.Correlation analysis between the results of cognition assessment and drinking characteristics in alcohol-dependent groups: the alcohol addiction time of alcohol-dependent patients was positively correlated with the TMT-B score by Spearman correlation analysis(r=0.437,P<0.05);The VFT score was positively correlated by theSpearman correlation analysis score(r=0.453,P<0.05).4.Correlation analysis between brain area and drinking characteristics in alcohol-dependent group: The ALFF value of the left frontal gyrus of patients with alcohol dependence was negatively correlated with the sustained drinking time by Spearman correlation analysis(r=-0.465,P<0.05).There was no significant correlation between the remaining differential brain regions and the various drinking characteristics analyzed by Spearman correlation.5.Correlation analysis between brain-related differences and cognitive assessment scores in the alcohol-dependent group: The ALFF value of the right frontal gyrus of the alcohol-dependent patients was positively correlated with the VFT score by Pearson correlation analysis(r=0.495,P<0.05).The right upper iliac crest,the left frontal gyrus,the left cingulate gyrus,the left occipital lobe,the left cerebellar posterior lobe ALFF value and its own neuropsychological assessment scores were analyzed by Pearson correlation,and no significant correlation was found.Sex.Conclusions1.Alcohol dependent patients have overall cognitive,learning,attention,speech,and executive cognitive impairment.2.Alcohol dependent patients have changes in brain area such as right upper iliac crest,left frontal gyrus,right frontal middle gyrus,left cingulate gyrus,left occipital lobe,and left cerebellar posterior lobe.3.The alcohol-dependent patient's left upper frontal ALFF value was positively correlated with his continuous drinking time.4.The ALFF value of the right frontal gyrus of the alcohol-dependent patients was positively correlated with the language fluency test score. |
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