Study Of Fractional Amplitude Of Low Frequency Fluctuation (fALFF) Of Resting-state Functional Magnetic Resonance Imaging (fMRI) Of The First-episode Tourette Syndrome

Objective: To explore the characteristics of fractional amplitude of low frequencyfluctuation (fALFF) of resting-state functional magnetic resonance imaging (fMRI) ofthe first-episode Tourette syndrome.Method: Sixteen subjects were all recruited from the out-patient department ofpediatrics of Beijing Anding Hospital, Capital Medical University and were all first-episodeTourette syndrome patients (male:13, female:3; age:6~16years old; mean age:11.00±2.92years old; mean receiveing education time:5.06±2.86years). Sixteen gender-,age-, and education-matched healthy subjects participated in this study. All thesubjects were experienced resting-state fMRI scans and fALFF were calculated inthree frequency range:0.01~0.1Hz. Independent-samples T Test was performedbetween the two groups. P<0.005was used to determine the significance.Results: The TS patients showed a significant increase in fALFF in the left fusiformgyru（st=4.36, P<0.05）, right putame（nt=3.81, P<0.05）. In addition, fALFF decreaseswere found in the left pars triangularis of gyrus frontalis inferior（t=-6.13, P<0.05）,right middle frontal gyrus（t=-4.35, P<0.05）, left superior frontal gyrus（t=-4.51,P<0.05）, left middle occipital gyrus（t=-6.13, P<0.05）, left rolandic operculum（t=-4.58, P<0.05）and right rolandic operculum（t=-4.28, P<0.05）in the TS patients.Conclusions: There are abnormal activities in some brain areas and may implicatethe underlying neurophysiological mechanism in TS.