Analysis Of Influence Factors Of Coronary Artery Lesions In 540 Patients Undergoing Coronary Angiography

Objective:This study aims to analyze patients with coronary angiography by collecting general demographic characteristics,behavioral habits,coronary angiography results,and laboratory findings of patients undergoing coronary angiography from June 2017 to June 2018 in Jilin Provincial People's Hospital.The status of coronary artery disease and the influence factors of coronary artery disease degree provide a theoretical basis for early prediction of coronary artery atherosclerotic heart disease(CAD)patients with increased severity of coronary artery disease and improved clinical treatment of CAD.Methods:540 patients with coronary angiography in Jilin Provincial People's Hospital from June 2017 to June 2018 were enrolled.Read patient cases and collect the following information: gender,age,place of residence,diabetes and hypertension,past medical history,allergy history,tobacco and alcohol history,clinical indicators(such as blood routine,coagulation function,liver and kidney function,hypersensitivity C reaction Examination of protein,electrolyte status and infection index,etc.,),clinical symptoms and signs,coronary angiography results.Epi Data 3.1 software was used to establish the database,and SPSS 24.0 statistical software was used for data analysis.For continuous variables,if the normal distribution is consistent,the mean ± standard deviation(`X ± SD)is used for statistical description.If the normal distribution is not met,the median and quartiles are used for description.For qualitative data,the adoption rate and composition ratio(%)are statistically described.In the quantitative data,if the normal distribution is satisfied,the comparison between the two groups is performed by t test;the comparison between the three groups is analyzed by analysis of variance,and the comparison between the two groups is performed by LSD;if the normal distribution is not satisfied,Using the rank sum test;Univariate analysis P < 0.1 variables were included in multi-class logistic regression analysis.In this study,the dependent variable is an ordered categorical variable,and the parallel line test is first performed.If the parallel line test is satisfied,the ordered classification logistic regression model is used.If not,the disordered logistic regression model is used.The difference was statistically significant at P < 0.05.Results:1.The average age of the 540 patients undergoing coronary angiography was 59.91 ± 9.83 years old,among which 333 were males,accounting for 61.67%,and 207 were females,accounting for 38.33%.2.Diagnosis of coronary heart disease by coronary angiography: 442 cases were diagnosed as coronary heart disease by coronary angiography,accounting for 81.85% of the total;The diagnostic results in coronary angiography were taken as the gold standard,the sensitivity of preoperative CAD diagnosis was 14.48%,the specificity was 97.96%,the rate of missed diagnosis was 85.52%,and the rate of misdiagnosis was 2.04%.3.Number of branches in coronary artery lesions: 54 cases of 0 branches,accounting for 10.02%,122 cases of 1 branch,accounting for 22.63%,155 cases of 2 branches,accounting for 28.76%,and 208 cases of 3 branches,accounting for 38.59%.4.According to the Gensini integral score standard,the degree of coronary artery disease was determined: 111 cases were mild,accounting for 23.52%.Moderate 68 cases,14.41%;A total of 293 cases were severe,accounting for 62.08%.5.Multivariate analysis of factors influencing degree of coronary artery lesion: Family history of coronary heart disease,mean platelet volume and hypersensitive c-reactive protein content are risk factors for moderate coronary artery disease.Compared with mild coronary artery disease,those with family history of coronary heart disease are 6.093 times more likely to have moderate coronary artery disease than those without family history of coronary heart disease(OR=6.093,95%CI: 1.408~26.375).For each unit increase of MPV and hs-CRP,the risk of moderate coronary artery disease was 1.938 times(OR=1.938,95%CI: 1.881~1.999)and 1.623 times(OR=1.623,95%CI: 1.447~1.870),repectively.Age,hypertension and atherosclerosis index are factors that affect severe coronary artery disease.The risk of severe coronary artery disease was 0.315 times(OR=0.699,95%CI: 0.151~0.655)and 0.555 times(OR=0.555,95%CI: 0.324 to 0.952)in those aged 50 or less and 51 to 64 than that in those aged 65,repectively.The risk of severe coronary artery disease in patients with hypertension was 2.479 times than that in those without hypertension(OR=2.479,95%CI: 1.334~4.606).For each unit increase in the atherosclerosis index,the risk of severe coronary artery disease is 1.478 times(OR=1.478,95%CI: 1.114~1.962).Conclusion:In patients undergoing coronary angiography,the proportion of patients with severe coronary lesions was 62.08%,the proportion of patients with moderate lesions was at least 23.52%,and the number of lesions was more than 2 and more.Family history of coronary heart disease,mean platelet volume and hypersensitive c-reactive protein content are the influencing factors of moderate coronary artery disease;age,hypertension and atherosclerosis index are the major influencing factors for severe coronary artery disease.