Relationship Between Lung Function And Metabolic Syndrome

Objective: By monitoring the lung function in patients with metabolic syndrome(MS),including ventilatory function and diffusion function,to explore MS and it's components influence on lung function,and whether two or more different metabolic have cumulative effect on lung function or not.Methods: From November 2016 to October 2017,120 cases of experimental group were selected from the hospitalized patients who according to the International Diabetes Federation(IDF)consensus worldwide definition of MS.120 cases of the control group were selected from the health examiner of the medical center.All the patients underwent a careful history,physical examination,spirometric lung function test and laboratory examination.Single factor analysis including t-test,rank sum test and Chisquare test were used to compare the differences between two groups.Single factor analysis of variance was used to evaluate the relationship between pulmonary function and different components of metabolic syndrome.Multiple linear regression analysis were used to assess the relation between lung function and MS adjusted for sex,age,height,weight.Results: There was no significant difference in age between Group-MS and Group-non-MS.BMI,SBP,DBP,Waist circumference,TG,FPG in Group-MS were significantly higher than that in Group-non-MS(P<0.001).HDL in Group-MS was significantly lower than that in Group-non-MS(P<0.001).FVC%Pred in Group-MS was lower than Group-non-MS among male,female,50-59 years,60-69 years,70-79 years and all subjects(t:-3.852,P<0.001;t:-1.328,P<0.05;t:-3.06,P<0.05;t:-2.872,P<0.05;t:-4.172,P<0.001).FEV1%Pred in Group-MS was lower than Group-non-MS among male,60-69 years,70-79 years and all subjects(t:-3.778,P<0.001;t:-3.23,P<0.05;t:-3.007,P<0.05;t:-3.820,P<0.001).FEV1/FVC of Group-MS was lower than Group-non-MS in 70-79 years group(t:-2.137,P<0.05).In male,female,40-49 years,50-59 years,60-69 years,70-79 years and all subjects,DLCO%pred in Group-MS was significantly lower than Group-non-MS(t:-7.099,P<0.001;t:-9.476,P<0.001;t:-4.736,P<0.001;t:-6.06,P<0.001;t:-6.72,P<0.001;t:-7.937,P<0.001 t:-11.650,P<0.001).With the components of metabolic syndrome gather increase,FVC%Pred,FEV1%Pred,DLCO%pred were significantly reduced(F:4.359,P<0.05;t:5.055,P<0.05;F:18.79,P<0.001).In the relation between components of MS and lung function,Model 1 was MS components respectively entered into multiple linear regression equation,Model 2 was all the MS components entered into the equation.With waist circumference,SBP,TG increased and HDL decreased,FVC%Pred falls and affect to restrictive ventilation dysfunction.In model 1,partial regression coefficient ? and P values with FVC%Pred were(-0.041,<0.001),(-0.029,<0.001),(-0.026,0.005),(-0.025,0.023).In model 2,they were(-0.043,<0.001),(-0.024,0.002),(-0.021,0.004),(-0.020,0.020).In addition,with waist circumference,SBP,TG increased and HDL decreased,FEV1%Pred falls and tended to obstructive ventilation dysfunction.In model 1,the partial regression coefficient ? and P values of FEV1%Pred were(-0.035,<0.001),(-0.017,0.039),(-0.020,0.023),(-0.025,0.013).In model 2,TG and HDL had little impact on FEV1%Pred,waist circumference and SBP's partial regression coefficient ? and P values of FEV1%Pred were(-0.042,<0.001),(-0.012,0.002).Elevated FPG did not cause related ventilatory function decline.DLCO%Pred decline with waist circumference,systolic blood pressure,TG,FPG increased and HDL decreased.In model 1,the partial regression coefficient ? and P values of DLCO%Pred were(-0.124,<0.001),(-0.030,<0.001),(-0.022,<0.001),(-0.021,<0.001),(-0.015,<0.001).Inmodel 2,they were(-0.119,<0.001),(-0.033,0.002),(-0.023,0.011),(-0.024,0.011),(-0.016,<0.001).Conclusions: The Group-MS was more likely to suffer impairment of lung function than the Group-non-MS especially among males and the elderly.In the components of MS,waist circumference and systolic blood pressure can make atendency of mixed ventilation dysfunction.DLCO%Pred declined with waist circumference,systolic blood pressure,TG,FPG increased and HDL decreased.Indicating that systolic blood pressure and waist circumference are important predictors of lung ventilatory function decline.Waist circumference,systolic blood pressure,TG,FPG and HDL are important predictors of lung diffusion function decline.With the increase of the composition of the metabolic syndrome,lung function damage is more likely to occur.