Changes Of Pulmonary Ventilation Function In Metabolic Syndrome And Its Related Factors

Objective: To investigate the changes of pulmonary ventilation function in metabolic syndrome and its effects on lung function.Methods: This study chose 127 healthy controls and patients with any components of the metabolic syndrome to underwent questionnaire investigation,physical examination, laboratory examination and lung function test in the first affiliated hospital of guangxi medical university from October 2015 to March 2016. According to the diagnostic criteria for metabolic syndrome in Chinese patients with type 2 diabetes prevention guidelines (2013 Edition), patients were divided into four groups : normal group, one metabolic disorder group,two metabolic disorders group and metabolic syndrome group. The clinical features and pulmonary function of four groups were compared by one-way ANOVA. According to body mass index, waist circumference, blood glucose,blood pressure, blood uric acid and carotid arteriosclerosis, fatty liver, subjects were divided into obese group, abdominal obesity group, hyperglycemia group,hypertension group, high uric acid group, carotid atherosclerosis group, fatty liver group and the control group. The differences of pulmonary ventilation function between the two groups were compared by two independent samples T-test. Multiple linear regression was used to evaluate the relationship between the components of metabolic syndrome and pulmonary ventilation function.Results: There were statistical differences in VC%pred,FVC%pred,FEVi%pred, FEVi/FVC, MVV%pred and MEF75%pred (P<0.05) among the four groups of normal group, one metabolic disorder group, two metabolic disorders group and metabolic syndrome group. VC%pred, FVC%pred,FEV1%pred, MVV%pred and FEV1/FVC in the metabolic syndrome group were significantly lower than those in the normal group (P<0.05). VC%pred,FVC%pred, FEV1%pred, MVV%pred and MEF75%pred in the metabolic syndrome group were significantly lower than those in the one metabolic disorder group (P< 0.05). FEV1/FVC in the two metabolic disorders group was significantly lower than these in the normal group (P<0.05). VC%pred,FVC%pred, FEV1%pred and MVV%pred in the hypertensive group were significantly lower than those in the control group (P< 0.05). FEV1%pred and FEVi/FVC in Fatty liver group were significantly lower than the control group(P<0.05). The components of metabolic syndrome were divided into multiple regression model. With the waist circumference and systolic blood pressure increased and the body mass index decreased, FVC%pred showed a downward trend. The partial regression coefficients and P value about waist circumference,systolic blood pressure and BMI in the linear regression equation of the FVC%pred is respectively (-0.534,0.011),(-0.221,0.043) , (1.674, 0.004)With the waist circumference increased and body mass index decreased ,FEV1%pred showed a downward trend. The partial regression coefficients and P values is respectively (1.185,0.034), (-0.495,0.014).Conclusion: As the components of the metabolism increasing, the lung ventilation function is in a downtrend. It is a mixed ventilation dysfunction.Hypertension and fatty liver can cause the decrease of pulmonary ventilation function. Pulmonary ventilation function is mainly related to the systolic blood pressure and waist circumference.