Diagnostic Value Of The Combination Of Heart-type Fatty Acid-binding Protein,copeptin And Cardiac TroponinT In Patients With Non-ST-elevation Myocardial Infarction

Background: Acute coronary syndrome(ACS)is one of the common medical emergency disease,it includes unstable angina pectoris(UAP),non-ST-elevation myocardial infarction(NSTEMI),and ST-elevation myocardial infarction(STEMI)etc.Because of lack of typical change of ECG and traditional cardiac markers in early stage,patients of NSTEMI are misdiagnosed frequently.Rapid and accurate diagnosis of NSTEMI and early identification are very important and help reduce the incidence of adverse events.Objective:To study the prognostic value of the combination of heart-type fatty acid-binding protein(H-FABP),copeptin and cardiac troponin T(cTnT)in patients with non-ST-segment elevation myocardial infarction(NSTEMI).Methods: A total of 111 patients treated in our department due to chest pain within 3 hours were recruited,including 58 cases of NSTEMI,22 cases of UAP and 31 cases of NCCP.H-FABP,copeptin,cTnT,cTnI and CKMB were measured in all patients.According to Gensini scoring system for quantitative determination of each vascular lesions,patients of NSTEMI were divided into 3 groups: low score group(14 cases),middle score group(19 cases),high score group(25 cases).According to ROC curve,the efficacy of each index in the early diagnosis of NSTEMI was determined.Result:The levels of H-FABP and copeptin rised with the increase of the myocardial ischemia and Gensini scores.The combination of H-FABP,copeptin and cTnT showed higher detection sensitivity(71.1%),specificity(72.6%).The AUC increased significantly(P<0.05)compared to that of cTnT,cTnI and CKMB.Conclusion:The combination of H-FABP,copeptin and cTnT shows better diagnosis efficiency of NSTEMI than cTnT,cTnI and CKMB.It can increases the diagnostic rate of NSTEMI,and also reflects the severity of coronary artery disease.