Clinical Study On The Treatment Of Reflux Esophagitis(middle-jiao Deficiency And Qireverse) By The Principle Of Pungent-sugariness Restricting Acid

Purpose: By observing theclinical efficacy ofreflux esophagitis patients(middle-jiao deficiency and Qireverse)treatedbyaddition and subtraction of Huangqi Jianzhong decoction,and compared with thetreatmentof pantoprazole Sodium Enteric-Coated Capsules,toobserve the difference of curative effect between the two groups,andthenexploretheclinical value of “ pungent-sugariness restrictingacid” principletreatingreflux esophagitis(middle-jiao deficiency and Qireverse)Methods: Sixtypatientswithreflux esophagitis(middle-jiao deficiency and Qireverse)met the inclusion criteria who were selected and randomly divided into control group(30cases)and treatment group(30cases).The two groups were educatedbytheaspectof food and lifestyle.thepatientsof treatment group weretreatedbyaddition and subtraction of Huangqi Jianzhong decoction,1 dose / day,3 times / day,1hoursbefore meals.thepatientsof control group weretreatedby pantoprazole Sodium Enteric-Coated Capsules,40mg/eachtime,1time/day,fasting orally in the morning.The two groups were treated with 8 weeks as 1 courses.Before and after treatment,the symptoms and signs of TCM,TCM syndrome scores,difference of gastroscopy effect andsideeffects were observed andrecorded.The data isusedby SPSS24.0 software for statistical and analysis.Results:1.Symptom:The P values of all the symptoms in the treatment group were less than 0.05 before and after the treatment,and the difference was statistically significant;The P values of thesymptom score aboutspit the gastric juice,fatigued spirit and lack of strength,dilute stool of control group were more than 0.05 before and after the treatment,andthere is no statistical significance in the difference;The P values of thesymptom score about belching,stomach pain,poor appetite,eat less bloating,gastrectasia of control group were less than 0.05,and the difference was statistically significant.The P values of twogroups' symptom score of spit the gastric juice,belching,gastrectasia,weak,dilute stool were less than 0.05 after the treatment,and the difference was statistically significant.The P values of twogroups' symptom score of belching,stomach pain,poor appetite,eat less bloating were more than 0.05 after the treatment,and there is no statistical significance in the difference.2.Syndrome score:Treatment group' average value before treatment is 16.07±3.07,after treatment is 6.17±4.74,and the difference was statistically significant(P<0.001);Control group' average value before treatment is 16.83±3.17,after treatment is 8.97 ± 3.89,and the difference was statistically significant(P <0.001);The difference of two groups' TCM syndrome scores was statistically significant(P<0.05)3.TCM Syndrome Points: After treatment,the scores of TCM syndromes before treatment in both groups were significantly different(P<0.01).The average of TCM syndrome scores of two groups after treatment were 3.64 ± 1.87 in treatment group and 5.58 ± 3.15 in control group,the difference was statistically significant(P<0.05).3.The curative effect of TCM Syndrome:In the treatment group,3 patients were cured,13 were markedly effective,10 were effective,and 4 were ineffective.The total effective rate was 86.67%.In the control group,1 patients were cured,7 were markedly effective,15 were effective,and 7 were ineffective.The total effective rate was 76.67%,the difference was statistically significant(P < 0.05).4.The effect of gastroscopy:In the treatment group,3 patients were cured,7 markedly effective,14 effective,6 invalid,the total effective rate was 80%,the control group was 2,effective 4,effective 16,invalid 8,the total effective rate was 73.33%,the difference was not statistically significant(P > 0.05).5.safety analysis: two groups of patients were not found obvious adverse reactions before and after treatment,review of blood,urine routine,stool routine + occult blood,ECG and renal function had no obvious abnormalities.Conclusions:1.Both the treatment group and the control group can improve the clinical symptoms of reflux esophagitis(middle-jiao deficiency and Qireverse),compared with pantoprazole Sodium Enteric-Coated Capsules treated by control group,addition and subtraction of Huangqi Jianzhong decoction had more treatment effect in improving symptoms such as spit the gastric juice,belching,gastrectasia,weak and dilute stool.2.compared with pantoprazole Sodium Enteric-Coated Capsules,addition and subtraction of Huangqi Jianzhong decoction have more treatment effect in the curative effect of TCM Syndrome of gastroesophageal reflux disease(middle-jiao deficiency and Qireverse).3.The treatment group and the control group have the same effect in improving the injury of the esophageal mucosa.4.The treatment of reflux esophagitis(middle-jiao deficiency and Qireverse)is safe and effective treated by addition and subtraction of Huangqi Jianzhong decoction,and the decoction has certain clinical application value.