A Meta Analysis Of The Therapeutic Effect And Safety Of Spleen-invigorating And Blood-activating Chinese Medicine Treatment On Nonalcoholic Steatohepatitis

BackgroundWith the economic development and changes in living habits,the prevalence of non-alcoholic fatty liver disease(NAFLD)has rapidly increased.At present,non-alcoholic steatohepatitis(NASH)has become the most common cause of cryptogenic cirrhosis and unexplained hepatocellular carcinoma(HCC).NASH has become a new challenge for the current liver disease.There is no specific treatment for NASH,and Chinese medicine has unique advantages in this regard.PurposeSystematic evaluation of the efficacy and safety of spleen-invigorating and blood-activating Chinese medicine treatment for NASH.MethodRetrieve information from CNKI database,Wanfang database,VIP database,Cochrane Library and PubMed.Under the inclusion exclusion criteria,randomized controlled trials(RCTs)for the treatment of NASH with spleen-invigorating and blood-activating Chinese medicine was selected before December 2017.Two researchers separately extracted data for quality evaluation and used Rev Man 5.3 statistical software for meta-analysis.ResultA total of 14 RCTs(1713 patients)were included in the study,of which 675 were in the experimental group and 642 in the control group were meta-analyzed.According to the results,the efficacy of spleen-stimulating and blood-activating for treating NASH patients was significantly better than conventional western medicine.And the treating therapy in serum liver enzyme(ALT,AST)and serum lipids(TG,TC)levels were significantly improved.ConclusionSpleen-invigorating and blood-activating Chinese medicine treatment of NASH patients is superior to conventional western medicine in terms of improvement of total effective rate and improvement of serum liver enzyme and serum lipids,and may have certain guiding significance for clinical practice.