| Backgroud and object Bladder cancer is one of the common malignant tumors of the urinary system.Non-muscle-invasive bladder cancer(NMIBC)accounted for 75%-85% in bladder cancer.At present,transurethral resection of bladder tumor(TURBt)is the main method for diagnosis and treatment of NMIBC.NMIBC has a higher recurrence rate after surgery,and simply performing TURBt can not effectively reduce the recurrence rate of NMIBC patients.National guidelines have confirmed that combined with intravesical instillation therapy can effectively reduce the recurrence rate of NMIBC.However,patients who receive bladder infusion therapy may develop complications such as urinary tract infections and reduce the quality of life of patients.At present,there is less research on the changes of urine routine and clinical symptoms in patients undergoing bladder instillation after TURBt.The purpose of this study was to investigate the changes of pyuria and clinical symptoms after bladder instillation in patients,and provide basis for clinicians to formulate corresponding prevention strategies.Methods To analyze patients with non-muscle-invasive bladder cancer who underwent continuous bladder instillation after TURBt,who were diagnosed and treated in the Urology Department of the Second Hospital of Tianjin Medical University from June 2017 to January 2018.Collect their clinical data and pathological diagnosis data.Urinary routine examinations were performed before each patient underwent intravesical instillation therapy,.and urine culture tests were performed if abnormalities were found.Let the patient fill in the core lower urinary tract symptom scale(including frequency of day and night urination,urinary urgency,urinary tract thinning,urinary fistula,dysuria,bladder pain,stress urinary incontinence,urge urinary incontinence,).Record each patient’s symptom score and the results of urine routine and urine culture.Each patient was monitored for 8 weeks.The weekly urine rate,severe pyuria rate,and bacteriuria rate were measured and observed in patients before the intravesical instillation therapy.Urine white blood cell data collected using Graph Pad.Prism.v5.0 were plotted into scattergrams to determine the trend of urinary leukocyte changes within 8 weeks after surgery.The Pearson correlation analysis was performed using the IBM SPSS 20.0 on patients’ postoperative pyuria and hematuria and the core lower urinary tract core symptom score scale.Results The postoperative pyogenic rate of NMIBC patients after TURBt was 82.6%,83.9%,83.6%,73.2%,70.0%,57.4%,44.8%,32.8%,respectively.Severe pyuria rates were 25.9%,23.2%,16.4%,17.5%,10.3%,9.3%,3.4%,and 1.6%,respectively.A total of 8 cases of postoperative bacteriuria were found,including 4 cases of E.coli(50%),1 case of Acinetobacter baumannii(12.5%),1 case of Klebsiella pneumoniae(12.5%),and 1 case of Staphylococcus epidermidis.(12.5%),1 case of enterococcus faecalis(12.5%).The mean score of the core lower urinary tract symptom score scale was: 10.81±3.96,10±3.33,9.38±3.12,8.61±2.87,7.7±2.52,7.22±2.36,6.75±2.48,6.17±2.59.Pearson correlation analysis of urinary leukocyte and core lower urinary tract symptom score scale: r=0.359,p<0.01.There is a significant correlation between the urinary leukocyte and the core lower urinary tract symptom score scale.Conclusion: 1.Pyogenicuria is a common phenomenon after TURBt in NMIBC patients.2.Patients with pyuria do not mean that they have urinary tract infections.3.The tendency of pyuria and bacteriuria with the prolongation of postoperative time and the increase of the number of infusion treatments gradually decreased.4.The symptoms of lower urinary tract irritation in patients with bladder instillation gradually decreased with the increase of the number of infusions. |
PDF Full Text Request